Oligomycin induced the proteasomal degradation of cyclin D1 protein

Mai Kanai, Satoru Iba, Ryoko Okada, Etsu Tashiro, Masaya Imoto

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1 Citation (Scopus)

Abstract

We searched for compounds that affect the cyclin D1/retinoblastoma protein pathway from the in-house natural product library using a recombinant adenovirus with the Cre/loxP-regulated cyclin D1 overexpression system, and we found that oligomycin inhibited cell growth more effectively in cyclin D1-overexpressing SW480 cells than in control SW480 cells. We also found that oligomycin reduced the expression levels of cyclin D1 protein and that this reduction is, at least in part, mediated by Thr-286 phosphorylation-dependent proteasomal degradation.

Original languageEnglish
Pages (from-to)425-429
Number of pages5
JournalJournal of Antibiotics
Volume62
Issue number8
DOIs
Publication statusPublished - 2009 Aug 1

Keywords

  • Cell growth inhibition
  • Chemosensitivity
  • Cyclin D1
  • E2F-1
  • PRB

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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    Kanai, M., Iba, S., Okada, R., Tashiro, E., & Imoto, M. (2009). Oligomycin induced the proteasomal degradation of cyclin D1 protein. Journal of Antibiotics, 62(8), 425-429. https://doi.org/10.1038/ja.2009.47