Omega-3 fatty acid-derived mediators that control inflammation and tissue homeostasis

Tomoaki Ishihara; Mio Yoshida; Makoto Arita

doi:10.1093/intimm/dxz001

Omega-3 fatty acid-derived mediators that control inflammation and tissue homeostasis

Tomoaki Ishihara, Mio Yoshida, Makoto Arita

School of Pharmacy

Research output: Contribution to journal › Review article › peer-review

88 Citations (Scopus)

Abstract

Omega-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, display a wide range of beneficial effects in humans and animals. Many of the biological functions of PUFAs are mediated via bioactive metabolites produced by fatty acid oxygenases such as cyclooxygenases, lipoxygenases and cytochrome P450 monooxygenases. Liquid chromatography-tandem mass spectrometry-based mediator lipidomics revealed a series of novel bioactive lipid mediators derived from omega-3 PUFAs. Here, we describe recent advances on omega-3 PUFA-derived mediators, mainly focusing on their enzymatic oxygenation pathway, and their biological functions in controlling inflammation and tissue homeostasis.

Original language	English
Pages (from-to)	559-567
Number of pages	9
Journal	International immunology
Volume	31
Issue number	9
DOIs	https://doi.org/10.1093/intimm/dxz001
Publication status	Published - 2019 Sept 1

Keywords

LC-MS/MS
anti-inflammation
lipid mediator
omega-3 fatty acid
oxygenase

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1093/intimm/dxz001

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title = "Omega-3 fatty acid-derived mediators that control inflammation and tissue homeostasis",

abstract = "Omega-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, display a wide range of beneficial effects in humans and animals. Many of the biological functions of PUFAs are mediated via bioactive metabolites produced by fatty acid oxygenases such as cyclooxygenases, lipoxygenases and cytochrome P450 monooxygenases. Liquid chromatography-tandem mass spectrometry-based mediator lipidomics revealed a series of novel bioactive lipid mediators derived from omega-3 PUFAs. Here, we describe recent advances on omega-3 PUFA-derived mediators, mainly focusing on their enzymatic oxygenation pathway, and their biological functions in controlling inflammation and tissue homeostasis.",

keywords = "LC-MS/MS, anti-inflammation, lipid mediator, omega-3 fatty acid, oxygenase",

author = "Tomoaki Ishihara and Mio Yoshida and Makoto Arita",

note = "Funding Information: We thank the Japan Society for the Promotion of Science KAKENHI JP15H05897, 15H05898, 15H04648 (M.A.), 17K18364 (T.I.), Aging Project of RIKEN (M.A., T.I.) and the ONO Medical Research Foundation (T.I.). Publisher Copyright: {\textcopyright} 2019 The Japanese Society for Immunology. 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",

year = "2019",

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doi = "10.1093/intimm/dxz001",

language = "English",

volume = "31",

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AU - Ishihara, Tomoaki

AU - Yoshida, Mio

AU - Arita, Makoto

N1 - Funding Information: We thank the Japan Society for the Promotion of Science KAKENHI JP15H05897, 15H05898, 15H04648 (M.A.), 17K18364 (T.I.), Aging Project of RIKEN (M.A., T.I.) and the ONO Medical Research Foundation (T.I.). Publisher Copyright: © 2019 The Japanese Society for Immunology. 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Omega-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, display a wide range of beneficial effects in humans and animals. Many of the biological functions of PUFAs are mediated via bioactive metabolites produced by fatty acid oxygenases such as cyclooxygenases, lipoxygenases and cytochrome P450 monooxygenases. Liquid chromatography-tandem mass spectrometry-based mediator lipidomics revealed a series of novel bioactive lipid mediators derived from omega-3 PUFAs. Here, we describe recent advances on omega-3 PUFA-derived mediators, mainly focusing on their enzymatic oxygenation pathway, and their biological functions in controlling inflammation and tissue homeostasis.

AB - Omega-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, display a wide range of beneficial effects in humans and animals. Many of the biological functions of PUFAs are mediated via bioactive metabolites produced by fatty acid oxygenases such as cyclooxygenases, lipoxygenases and cytochrome P450 monooxygenases. Liquid chromatography-tandem mass spectrometry-based mediator lipidomics revealed a series of novel bioactive lipid mediators derived from omega-3 PUFAs. Here, we describe recent advances on omega-3 PUFA-derived mediators, mainly focusing on their enzymatic oxygenation pathway, and their biological functions in controlling inflammation and tissue homeostasis.

KW - LC-MS/MS

KW - anti-inflammation

KW - lipid mediator

KW - omega-3 fatty acid

KW - oxygenase

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Omega-3 fatty acid-derived mediators that control inflammation and tissue homeostasis

Abstract

Keywords

ASJC Scopus subject areas

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