Omega-3 fatty acid metabolism and regulation of inflammation

Yosuke Isobe, Makoto Arita

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Increasing evidence from both human and animal studies has demonstrated that omega-3 polyunsaturated fatty acids (PUFAs), primarily eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), can suppress inflammation and play a beneficial role in a variety of inflammation-related human diseases, such as inflammatory bowel disease, rheumatoid arthritis, asthma, cancer, and cardiovascular diseases. Omega-3 PUFAs serve as substrates for the production of potent bioactive anti-inflammatory lipid mediators such as resolvins. Herein wereview recent advances in understanding the formation and action of these mediators, especially focusing on the LC-ESI-MS/MS-based lipidomics approach and on recently identified bioactive compounds with potent anti-inflammatory properties.

Original languageEnglish
Title of host publicationBioactive Lipid Mediators: Current Reviews and Protocols
PublisherSpringer Japan
Pages155-162
Number of pages8
ISBN (Electronic)9784431556695
ISBN (Print)9784431556688
DOIs
Publication statusPublished - 2015 Jan 1
Externally publishedYes

Keywords

  • Anti-inflammation
  • LC-MS/MS
  • Lipid mediator
  • Lipidomics
  • Lipoxygenase
  • Omega-3 PUFA

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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  • Cite this

    Isobe, Y., & Arita, M. (2015). Omega-3 fatty acid metabolism and regulation of inflammation . In Bioactive Lipid Mediators: Current Reviews and Protocols (pp. 155-162). Springer Japan. https://doi.org/10.1007/978-4-431-55669-5_11