Omeprazole, a Proton Pump Inhibitor, Reduces the Secretion, Synthesis and Gene Expression of Pepsinogen in the Rat Stomach

N. Kakei, M. Ichinose, S. Tsukada, M. Tatematsu, N. Tezuka, Naohisa Yahagi, M. Matsushima, K. Miki, K. Kurokawa, K. Takahashi, H. Fukamachi

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Abstract

Omeprazole, a proton pump inhibitor, dose-dependently inhibited pepsinogen secretion as well as acid secretion in the rat glandular stomach. The reduction in the secretion was rapid and was followed by a decrease in the mRNA levels. The inhibitory effect of omeprazole on pepsinogen secretion and its effect on the mRNA level showed similar dose-response relationship, suggesting that pepsinogen secretion and the gene expression are regulated coordinately. Consistent with the reduction in the mRNA levels, protein synthesis was reduced. However, intracellular stores of pepsinogen increased in pepsinogen-producing cells, indicating that the inhibitory effect of omeprazole on pepsinogen secretion is greater than on its synthesis. Reducing the secretion, synthesis and gene expression of pepsinogen, omeprazole has a potent effect on pepsinogen-producing cells in vivo, as well as on parietal cells, in the rat glandular stomach.

Original languageEnglish
Pages (from-to)997-1004
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume195
Issue number2
DOIs
Publication statusPublished - 1993 Sep 15
Externally publishedYes

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ASJC Scopus subject areas

  • Molecular Biology
  • Biophysics
  • Biochemistry

Cite this

Kakei, N., Ichinose, M., Tsukada, S., Tatematsu, M., Tezuka, N., Yahagi, N., Matsushima, M., Miki, K., Kurokawa, K., Takahashi, K., & Fukamachi, H. (1993). Omeprazole, a Proton Pump Inhibitor, Reduces the Secretion, Synthesis and Gene Expression of Pepsinogen in the Rat Stomach. Biochemical and Biophysical Research Communications, 195(2), 997-1004. https://doi.org/10.1006/bbrc.1993.2143