On the correlation between T2 and tissue diffusion coefficients in exercised muscle: Quantitative measurements at 3T within the tibialis anterior

Zaid Q. Ababneh, Riad Ababneh, Stephan E. Maier, Carl S. Winalski, Koichi Oshio, Anas M. Ababneh, Robert V. Mulkern

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Purpose: To assess the transverse relaxation time T2 and diffusion coefficient D before and following exercise in the tibialis anterior muscle and determine whether T2 and D values were correlated. Methods: Measurements of T2 and D were performed at 3 T within axial slices through the calf muscles of six healthy volunteers at 95 s intervals before and for 10-12 min after a dorsiflexion exercise to exhaustion. Results: The mean ± standard deviation (SD) of T2 and D before exercise were 32 ± 1.55 ms and 1.52 ± 0.15 μm2/ms, and after exercise were 43 ± 2.5 ms and 1.72 ± 0.13 μm2/ms, respectively. The mean ± SD inter-individual recovery times of the % change in T2 and D after exercise were 7.9 ± 4.2 and 10.9 ± 7.0 min, respectively. The T2 and D values showed a significant correlation throughout the experiments (r 2 = 0.45). Conclusions: The increase in T2 of skeletal muscle after exercise is correlated with the increase of the diffusion coefficient D and the recovery times appear similar, indicating that any model used to explain T2 increases with exercise must also account for increased diffusion coefficients.

Original languageEnglish
Pages (from-to)273-278
Number of pages6
JournalMagnetic Resonance Materials in Physics, Biology and Medicine
Volume21
Issue number4
DOIs
Publication statusPublished - 2008 Aug
Externally publishedYes

Fingerprint

Exercise
Muscles
Healthy Volunteers
Skeletal Muscle

Keywords

  • Diffusion coefficient
  • Exercise muscle
  • Magnetic resonance imaging
  • Transverse relaxation time

ASJC Scopus subject areas

  • Biophysics
  • Genetics

Cite this

On the correlation between T2 and tissue diffusion coefficients in exercised muscle : Quantitative measurements at 3T within the tibialis anterior. / Ababneh, Zaid Q.; Ababneh, Riad; Maier, Stephan E.; Winalski, Carl S.; Oshio, Koichi; Ababneh, Anas M.; Mulkern, Robert V.

In: Magnetic Resonance Materials in Physics, Biology and Medicine, Vol. 21, No. 4, 08.2008, p. 273-278.

Research output: Contribution to journalArticle

Ababneh, Zaid Q. ; Ababneh, Riad ; Maier, Stephan E. ; Winalski, Carl S. ; Oshio, Koichi ; Ababneh, Anas M. ; Mulkern, Robert V. / On the correlation between T2 and tissue diffusion coefficients in exercised muscle : Quantitative measurements at 3T within the tibialis anterior. In: Magnetic Resonance Materials in Physics, Biology and Medicine. 2008 ; Vol. 21, No. 4. pp. 273-278.
@article{41475ba9493a4ac08b61cef92530e229,
title = "On the correlation between T2 and tissue diffusion coefficients in exercised muscle: Quantitative measurements at 3T within the tibialis anterior",
abstract = "Purpose: To assess the transverse relaxation time T2 and diffusion coefficient D before and following exercise in the tibialis anterior muscle and determine whether T2 and D values were correlated. Methods: Measurements of T2 and D were performed at 3 T within axial slices through the calf muscles of six healthy volunteers at 95 s intervals before and for 10-12 min after a dorsiflexion exercise to exhaustion. Results: The mean ± standard deviation (SD) of T2 and D before exercise were 32 ± 1.55 ms and 1.52 ± 0.15 μm2/ms, and after exercise were 43 ± 2.5 ms and 1.72 ± 0.13 μm2/ms, respectively. The mean ± SD inter-individual recovery times of the {\%} change in T2 and D after exercise were 7.9 ± 4.2 and 10.9 ± 7.0 min, respectively. The T2 and D values showed a significant correlation throughout the experiments (r 2 = 0.45). Conclusions: The increase in T2 of skeletal muscle after exercise is correlated with the increase of the diffusion coefficient D and the recovery times appear similar, indicating that any model used to explain T2 increases with exercise must also account for increased diffusion coefficients.",
keywords = "Diffusion coefficient, Exercise muscle, Magnetic resonance imaging, Transverse relaxation time",
author = "Ababneh, {Zaid Q.} and Riad Ababneh and Maier, {Stephan E.} and Winalski, {Carl S.} and Koichi Oshio and Ababneh, {Anas M.} and Mulkern, {Robert V.}",
year = "2008",
month = "8",
doi = "10.1007/s10334-008-0120-8",
language = "English",
volume = "21",
pages = "273--278",
journal = "Magnetic Resonance Materials in Physics, Biology, and Medicine",
issn = "0968-5243",
publisher = "Springer Verlag",
number = "4",

}

TY - JOUR

T1 - On the correlation between T2 and tissue diffusion coefficients in exercised muscle

T2 - Quantitative measurements at 3T within the tibialis anterior

AU - Ababneh, Zaid Q.

AU - Ababneh, Riad

AU - Maier, Stephan E.

AU - Winalski, Carl S.

AU - Oshio, Koichi

AU - Ababneh, Anas M.

AU - Mulkern, Robert V.

PY - 2008/8

Y1 - 2008/8

N2 - Purpose: To assess the transverse relaxation time T2 and diffusion coefficient D before and following exercise in the tibialis anterior muscle and determine whether T2 and D values were correlated. Methods: Measurements of T2 and D were performed at 3 T within axial slices through the calf muscles of six healthy volunteers at 95 s intervals before and for 10-12 min after a dorsiflexion exercise to exhaustion. Results: The mean ± standard deviation (SD) of T2 and D before exercise were 32 ± 1.55 ms and 1.52 ± 0.15 μm2/ms, and after exercise were 43 ± 2.5 ms and 1.72 ± 0.13 μm2/ms, respectively. The mean ± SD inter-individual recovery times of the % change in T2 and D after exercise were 7.9 ± 4.2 and 10.9 ± 7.0 min, respectively. The T2 and D values showed a significant correlation throughout the experiments (r 2 = 0.45). Conclusions: The increase in T2 of skeletal muscle after exercise is correlated with the increase of the diffusion coefficient D and the recovery times appear similar, indicating that any model used to explain T2 increases with exercise must also account for increased diffusion coefficients.

AB - Purpose: To assess the transverse relaxation time T2 and diffusion coefficient D before and following exercise in the tibialis anterior muscle and determine whether T2 and D values were correlated. Methods: Measurements of T2 and D were performed at 3 T within axial slices through the calf muscles of six healthy volunteers at 95 s intervals before and for 10-12 min after a dorsiflexion exercise to exhaustion. Results: The mean ± standard deviation (SD) of T2 and D before exercise were 32 ± 1.55 ms and 1.52 ± 0.15 μm2/ms, and after exercise were 43 ± 2.5 ms and 1.72 ± 0.13 μm2/ms, respectively. The mean ± SD inter-individual recovery times of the % change in T2 and D after exercise were 7.9 ± 4.2 and 10.9 ± 7.0 min, respectively. The T2 and D values showed a significant correlation throughout the experiments (r 2 = 0.45). Conclusions: The increase in T2 of skeletal muscle after exercise is correlated with the increase of the diffusion coefficient D and the recovery times appear similar, indicating that any model used to explain T2 increases with exercise must also account for increased diffusion coefficients.

KW - Diffusion coefficient

KW - Exercise muscle

KW - Magnetic resonance imaging

KW - Transverse relaxation time

UR - http://www.scopus.com/inward/record.url?scp=49249126731&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=49249126731&partnerID=8YFLogxK

U2 - 10.1007/s10334-008-0120-8

DO - 10.1007/s10334-008-0120-8

M3 - Article

C2 - 18633660

AN - SCOPUS:49249126731

VL - 21

SP - 273

EP - 278

JO - Magnetic Resonance Materials in Physics, Biology, and Medicine

JF - Magnetic Resonance Materials in Physics, Biology, and Medicine

SN - 0968-5243

IS - 4

ER -