On the correlation between T2 and tissue diffusion coefficients in exercised muscle: Quantitative measurements at 3T within the tibialis anterior

Zaid Q. Ababneh, Riad Ababneh, Stephan E. Maier, Carl S. Winalski, Koichi Oshio, Anas M. Ababneh, Robert V. Mulkern

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Purpose: To assess the transverse relaxation time T2 and diffusion coefficient D before and following exercise in the tibialis anterior muscle and determine whether T2 and D values were correlated. Methods: Measurements of T2 and D were performed at 3 T within axial slices through the calf muscles of six healthy volunteers at 95 s intervals before and for 10-12 min after a dorsiflexion exercise to exhaustion. Results: The mean ± standard deviation (SD) of T2 and D before exercise were 32 ± 1.55 ms and 1.52 ± 0.15 μm2/ms, and after exercise were 43 ± 2.5 ms and 1.72 ± 0.13 μm2/ms, respectively. The mean ± SD inter-individual recovery times of the % change in T2 and D after exercise were 7.9 ± 4.2 and 10.9 ± 7.0 min, respectively. The T2 and D values showed a significant correlation throughout the experiments (r 2 = 0.45). Conclusions: The increase in T2 of skeletal muscle after exercise is correlated with the increase of the diffusion coefficient D and the recovery times appear similar, indicating that any model used to explain T2 increases with exercise must also account for increased diffusion coefficients.

Original languageEnglish
Pages (from-to)273-278
Number of pages6
JournalMagnetic Resonance Materials in Physics, Biology and Medicine
Volume21
Issue number4
DOIs
Publication statusPublished - 2008 Aug 1
Externally publishedYes

Keywords

  • Diffusion coefficient
  • Exercise muscle
  • Magnetic resonance imaging
  • Transverse relaxation time

ASJC Scopus subject areas

  • Biophysics
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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