On the interplay of gene positioning and the role of rho-independent terminators in Escherichia coli

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The majority of intrinsic rho-independent terminator signals, reported to consist of stable hairpin structures followed by T-rich regions, possess the potential to operate bi-directionally and to induce transcription terminations on both strands of the DNA duplex in Escherichia coli. By using RNAMotif software, we investigated the distributions of termination motifs around the 3′-ends of overlapping and non-overlapping genes at the genomic level. We suggest that the positions of compactly encoded E. coli genes and rho-independent terminators are optimized to terminate the adjoining genes on their antisense strands efficiently, and not to mis-terminate overlapping transcripts, due to their bi-directional properties.

Original languageEnglish
Pages (from-to)6909-6914
Number of pages6
JournalFEBS Letters
Volume580
Issue number30
DOIs
Publication statusPublished - 2006 Dec 22

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Escherichia coli
Genes
Transcription
Software
DNA

Keywords

  • Bioinformatics
  • Operon
  • Overlapping genes
  • Rho-independent terminator
  • RNAMotif

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

On the interplay of gene positioning and the role of rho-independent terminators in Escherichia coli. / Yachie, Nozomu; Arakawa, Kazuharu; Tomita, Masaru.

In: FEBS Letters, Vol. 580, No. 30, 22.12.2006, p. 6909-6914.

Research output: Contribution to journalArticle

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