On the synchrony of morphological and molecular signaling events in cell migration

Justin Dauwels; Yuki Tsukada; Yuichi Sakumura; Shin Ishii; Kazuhiro Aoki; Takeshi Nakamura; Michiyuki Matsuda; François Vialatte; Andrzej Cichocki

doi:10.1007/978-3-642-02490-0_58

On the synchrony of morphological and molecular signaling events in cell migration

Justin Dauwels, Yuki Tsukada, Yuichi Sakumura, Shin Ishii, Kazuhiro Aoki, Takeshi Nakamura, Michiyuki Matsuda, François Vialatte, Andrzej Cichocki

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

This paper investigates the dynamics of cell migration, which is the movement of a cell towards a certain target area. More specifically, the objective is to analyze the causal interdependence between cellular- morphological events and molecular-signaling events. To this end, a novel data analysis method is developed: first the local morphological changes and molecular signaling events are determined by means of edge evolution tracking (EET), next the interdependence of those events is quantified through the method of stochastic event synchrony (SES). The proposed method is applied to time-lapse fluorescence resonance energy transfer (FRET) images of Rac1 activity in motile HT1080 cells; the protein Rac1 is well known to induce filamentous structures that enable cells to migrate. Results show a significant delay between local Rac1 activity events and morphological events. This observation provides new insights into the dynamic relationship between cellular- morphological change and molecular-signaling of migrating cells, and may pave the way to novel biophysical models of cell migration.

Original language	English
Title of host publication	Advances in Neuro-Information Processing - 15th International Conference, ICONIP 2008, Revised Selected Papers
Pages	469-477
Number of pages	9
Edition	PART 1
DOIs	https://doi.org/10.1007/978-3-642-02490-0_58
Publication status	Published - 2009
Externally published	Yes
Event	15th International Conference on Neuro-Information Processing, ICONIP 2008 - Auckland, New Zealand Duration: 2008 Nov 25 → 2008 Nov 28

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Number	PART 1
Volume	5506 LNCS
ISSN (Print)	0302-9743
ISSN (Electronic)	1611-3349

Conference

Conference	15th International Conference on Neuro-Information Processing, ICONIP 2008
Country/Territory	New Zealand
City	Auckland
Period	08/11/25 → 08/11/28

ASJC Scopus subject areas

Theoretical Computer Science
Computer Science(all)

Access to Document

10.1007/978-3-642-02490-0_58

Cite this

Dauwels, J., Tsukada, Y., Sakumura, Y., Ishii, S., Aoki, K., Nakamura, T., Matsuda, M., Vialatte, F., & Cichocki, A. (2009). On the synchrony of morphological and molecular signaling events in cell migration. In Advances in Neuro-Information Processing - 15th International Conference, ICONIP 2008, Revised Selected Papers (PART 1 ed., pp. 469-477). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 5506 LNCS, No. PART 1). https://doi.org/10.1007/978-3-642-02490-0_58

On the synchrony of morphological and molecular signaling events in cell migration. / Dauwels, Justin; Tsukada, Yuki; Sakumura, Yuichi et al.
Advances in Neuro-Information Processing - 15th International Conference, ICONIP 2008, Revised Selected Papers. PART 1. ed. 2009. p. 469-477 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 5506 LNCS, No. PART 1).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Dauwels, J, Tsukada, Y, Sakumura, Y, Ishii, S, Aoki, K, Nakamura, T, Matsuda, M, Vialatte, F & Cichocki, A 2009, On the synchrony of morphological and molecular signaling events in cell migration. in Advances in Neuro-Information Processing - 15th International Conference, ICONIP 2008, Revised Selected Papers. PART 1 edn, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), no. PART 1, vol. 5506 LNCS, pp. 469-477, 15th International Conference on Neuro-Information Processing, ICONIP 2008, Auckland, New Zealand, 08/11/25. https://doi.org/10.1007/978-3-642-02490-0_58

Dauwels J, Tsukada Y, Sakumura Y, Ishii S, Aoki K, Nakamura T et al. On the synchrony of morphological and molecular signaling events in cell migration. In Advances in Neuro-Information Processing - 15th International Conference, ICONIP 2008, Revised Selected Papers. PART 1 ed. 2009. p. 469-477. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); PART 1). doi: 10.1007/978-3-642-02490-0_58

Dauwels, Justin ; Tsukada, Yuki ; Sakumura, Yuichi et al. / On the synchrony of morphological and molecular signaling events in cell migration. Advances in Neuro-Information Processing - 15th International Conference, ICONIP 2008, Revised Selected Papers. PART 1. ed. 2009. pp. 469-477 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); PART 1).

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AU - Nakamura, Takeshi

AU - Matsuda, Michiyuki

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AB - This paper investigates the dynamics of cell migration, which is the movement of a cell towards a certain target area. More specifically, the objective is to analyze the causal interdependence between cellular- morphological events and molecular-signaling events. To this end, a novel data analysis method is developed: first the local morphological changes and molecular signaling events are determined by means of edge evolution tracking (EET), next the interdependence of those events is quantified through the method of stochastic event synchrony (SES). The proposed method is applied to time-lapse fluorescence resonance energy transfer (FRET) images of Rac1 activity in motile HT1080 cells; the protein Rac1 is well known to induce filamentous structures that enable cells to migrate. Results show a significant delay between local Rac1 activity events and morphological events. This observation provides new insights into the dynamic relationship between cellular- morphological change and molecular-signaling of migrating cells, and may pave the way to novel biophysical models of cell migration.

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On the synchrony of morphological and molecular signaling events in cell migration

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