On-treatment predictions of success in peg-interferon/ribavirin treatment using a novel formula

Hidetsugu Saito, Hirotoshi Ebinuma, Keisuke Ojiro, Kanji Wakabayashi, Mika Inoue, Shinichiro Tada, Toshifumi Hibi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

AIM: To predict treatment success using only simple clinical data from peg-interferon plus ribavirin therapy for chronic hepatitis C. METHODS: We analyzed the clinical data of 176 patients with chronic hepatitis and hepatitis C virus genotype 1 who received 48 wk standard therapy, derived a predictive formula to assess a sustained virological response of the individual patient using a logistic regression model and confirmed the validity of this formula. The formula was constructed using data from the first 100 patients enrolled and validated using data from the remaining 76 patients. RESULTS: Sustained virological response was obtained in 83 (47.2%) of the patients and we derived formulae to predict sustained virological response at pretreatment and weeks 4, 12 and 24. The likelihood of sustained virological response could be predicted effectively by the formulae at weeks 4, 12 and 24 (the area under the curve of the receiver operating characteristic: 0.821, 0.802, and 0.891, respectively), but not at baseline (0.570). The formula at week 48 was also constructed and validation by test data achieved good prediction with 0.871 of the area under the curve of the receiver operating characteristic. Prediction by this formula was always superior to that by viral kinetics. CONCLUSION: These results suggested that our formula combined with viral kinetics provides a clear direction of therapy for each patient and enables the best tailored treatment.

Original languageEnglish
Pages (from-to)89-97
Number of pages9
JournalWorld Journal of Gastroenterology
Volume16
Issue number1
DOIs
Publication statusPublished - 2010 Jan 7

Fingerprint

Ribavirin
Interferons
ROC Curve
Area Under Curve
Therapeutics
Logistic Models
Chronic Hepatitis C
Chronic Hepatitis
Hepacivirus
Genotype

Keywords

  • Logistic regression analysis
  • Predictive formula
  • Prolongation of the therapy
  • Response-guided therapy
  • Viral kinetics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

On-treatment predictions of success in peg-interferon/ribavirin treatment using a novel formula. / Saito, Hidetsugu; Ebinuma, Hirotoshi; Ojiro, Keisuke; Wakabayashi, Kanji; Inoue, Mika; Tada, Shinichiro; Hibi, Toshifumi.

In: World Journal of Gastroenterology, Vol. 16, No. 1, 07.01.2010, p. 89-97.

Research output: Contribution to journalArticle

Saito, Hidetsugu ; Ebinuma, Hirotoshi ; Ojiro, Keisuke ; Wakabayashi, Kanji ; Inoue, Mika ; Tada, Shinichiro ; Hibi, Toshifumi. / On-treatment predictions of success in peg-interferon/ribavirin treatment using a novel formula. In: World Journal of Gastroenterology. 2010 ; Vol. 16, No. 1. pp. 89-97.
@article{82c45bc0d13e4436b3678247ed9e52c5,
title = "On-treatment predictions of success in peg-interferon/ribavirin treatment using a novel formula",
abstract = "AIM: To predict treatment success using only simple clinical data from peg-interferon plus ribavirin therapy for chronic hepatitis C. METHODS: We analyzed the clinical data of 176 patients with chronic hepatitis and hepatitis C virus genotype 1 who received 48 wk standard therapy, derived a predictive formula to assess a sustained virological response of the individual patient using a logistic regression model and confirmed the validity of this formula. The formula was constructed using data from the first 100 patients enrolled and validated using data from the remaining 76 patients. RESULTS: Sustained virological response was obtained in 83 (47.2{\%}) of the patients and we derived formulae to predict sustained virological response at pretreatment and weeks 4, 12 and 24. The likelihood of sustained virological response could be predicted effectively by the formulae at weeks 4, 12 and 24 (the area under the curve of the receiver operating characteristic: 0.821, 0.802, and 0.891, respectively), but not at baseline (0.570). The formula at week 48 was also constructed and validation by test data achieved good prediction with 0.871 of the area under the curve of the receiver operating characteristic. Prediction by this formula was always superior to that by viral kinetics. CONCLUSION: These results suggested that our formula combined with viral kinetics provides a clear direction of therapy for each patient and enables the best tailored treatment.",
keywords = "Logistic regression analysis, Predictive formula, Prolongation of the therapy, Response-guided therapy, Viral kinetics",
author = "Hidetsugu Saito and Hirotoshi Ebinuma and Keisuke Ojiro and Kanji Wakabayashi and Mika Inoue and Shinichiro Tada and Toshifumi Hibi",
year = "2010",
month = "1",
day = "7",
doi = "10.3748/wjg.v16.i1.89",
language = "English",
volume = "16",
pages = "89--97",
journal = "World Journal of Gastroenterology",
issn = "1007-9327",
publisher = "WJG Press",
number = "1",

}

TY - JOUR

T1 - On-treatment predictions of success in peg-interferon/ribavirin treatment using a novel formula

AU - Saito, Hidetsugu

AU - Ebinuma, Hirotoshi

AU - Ojiro, Keisuke

AU - Wakabayashi, Kanji

AU - Inoue, Mika

AU - Tada, Shinichiro

AU - Hibi, Toshifumi

PY - 2010/1/7

Y1 - 2010/1/7

N2 - AIM: To predict treatment success using only simple clinical data from peg-interferon plus ribavirin therapy for chronic hepatitis C. METHODS: We analyzed the clinical data of 176 patients with chronic hepatitis and hepatitis C virus genotype 1 who received 48 wk standard therapy, derived a predictive formula to assess a sustained virological response of the individual patient using a logistic regression model and confirmed the validity of this formula. The formula was constructed using data from the first 100 patients enrolled and validated using data from the remaining 76 patients. RESULTS: Sustained virological response was obtained in 83 (47.2%) of the patients and we derived formulae to predict sustained virological response at pretreatment and weeks 4, 12 and 24. The likelihood of sustained virological response could be predicted effectively by the formulae at weeks 4, 12 and 24 (the area under the curve of the receiver operating characteristic: 0.821, 0.802, and 0.891, respectively), but not at baseline (0.570). The formula at week 48 was also constructed and validation by test data achieved good prediction with 0.871 of the area under the curve of the receiver operating characteristic. Prediction by this formula was always superior to that by viral kinetics. CONCLUSION: These results suggested that our formula combined with viral kinetics provides a clear direction of therapy for each patient and enables the best tailored treatment.

AB - AIM: To predict treatment success using only simple clinical data from peg-interferon plus ribavirin therapy for chronic hepatitis C. METHODS: We analyzed the clinical data of 176 patients with chronic hepatitis and hepatitis C virus genotype 1 who received 48 wk standard therapy, derived a predictive formula to assess a sustained virological response of the individual patient using a logistic regression model and confirmed the validity of this formula. The formula was constructed using data from the first 100 patients enrolled and validated using data from the remaining 76 patients. RESULTS: Sustained virological response was obtained in 83 (47.2%) of the patients and we derived formulae to predict sustained virological response at pretreatment and weeks 4, 12 and 24. The likelihood of sustained virological response could be predicted effectively by the formulae at weeks 4, 12 and 24 (the area under the curve of the receiver operating characteristic: 0.821, 0.802, and 0.891, respectively), but not at baseline (0.570). The formula at week 48 was also constructed and validation by test data achieved good prediction with 0.871 of the area under the curve of the receiver operating characteristic. Prediction by this formula was always superior to that by viral kinetics. CONCLUSION: These results suggested that our formula combined with viral kinetics provides a clear direction of therapy for each patient and enables the best tailored treatment.

KW - Logistic regression analysis

KW - Predictive formula

KW - Prolongation of the therapy

KW - Response-guided therapy

KW - Viral kinetics

UR - http://www.scopus.com/inward/record.url?scp=75449099500&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=75449099500&partnerID=8YFLogxK

U2 - 10.3748/wjg.v16.i1.89

DO - 10.3748/wjg.v16.i1.89

M3 - Article

C2 - 20039454

AN - SCOPUS:75449099500

VL - 16

SP - 89

EP - 97

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

SN - 1007-9327

IS - 1

ER -