On verbal/nonverbal modality dependence of left and right inferior prefrontal activation during performance of flanker interference task

Hiroki M. Morimoto, Satoshi Hirose, Junichi Chikazoe, Koji Jimura, Tomoki Asari, Ken Ichiro Yamashita, Yasushi Miyashita, Seiki Konishi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

One of the most prevailing views on the functional localization of human cognition is the hemispheric specialization, wherein the left and right hemispheres are implicated primarily in verbal and nonverbal functions, respectively. Cognitive control is known to involve the lateral prefrontal cortex. However, it remains unclear whether the hemispheric specialization in the lateral prefrontal cortex can be observed in cognitive control per se, independent of sensory aspects of stimulus materials. In this functional magnetic resonance imaging study, we tested whether the verbal/nonverbal hemispheric specialization applies to the lateral prefrontal activation by investigating interference suppression, the ability to filter out irrelevant information in the environment. The flanker task was employed using a compound stimulus that contained a target and a flanker. The flanked stimulus was either a color word flanked by a colored patch or a colored patch flanked by a color word, which allowed us to manipulate the modality of the presented flanker stimulus from which interference originates, keeping the total stimulus modality balanced. The inferior frontal gyrus (IFG) showed prominent Modality-by-Hemisphere interaction in interference suppression, the left IFG being activated when a word flanker (plus a patch target) was presented and the right IFG being activated when a patch flanker (plus a word target) was presented. These results suggest that the verbal/nonverbal hemispheric specialization in the IFG can be explained by cognitive control processes per se, independent of sensory aspects of presented materials.

Original languageEnglish
Pages (from-to)2006-2014
Number of pages9
JournalJournal of Cognitive Neuroscience
Volume20
Issue number11
DOIs
Publication statusPublished - 2008 Nov
Externally publishedYes

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Prefrontal Cortex
Cerebral Dominance
Color
Aptitude
Cognition
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Cognitive Neuroscience

Cite this

On verbal/nonverbal modality dependence of left and right inferior prefrontal activation during performance of flanker interference task. / Morimoto, Hiroki M.; Hirose, Satoshi; Chikazoe, Junichi; Jimura, Koji; Asari, Tomoki; Yamashita, Ken Ichiro; Miyashita, Yasushi; Konishi, Seiki.

In: Journal of Cognitive Neuroscience, Vol. 20, No. 11, 11.2008, p. 2006-2014.

Research output: Contribution to journalArticle

Morimoto, Hiroki M. ; Hirose, Satoshi ; Chikazoe, Junichi ; Jimura, Koji ; Asari, Tomoki ; Yamashita, Ken Ichiro ; Miyashita, Yasushi ; Konishi, Seiki. / On verbal/nonverbal modality dependence of left and right inferior prefrontal activation during performance of flanker interference task. In: Journal of Cognitive Neuroscience. 2008 ; Vol. 20, No. 11. pp. 2006-2014.
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