Oncometabolites: Linking altered metabolism with cancer

Ming Yang, Tomoyoshi Soga, Patrick J. Pollard

Research output: Contribution to journalArticle

161 Citations (Scopus)

Abstract

The discovery of cancer-associated mutations in genes encoding key metabolic enzymes has provided a direct link between altered metabolism and cancer. Advances in mass spectrometry and nuclear magnetic resonance technologies have facilitated high-resolution metabolite profiling of cells and tumors and identified the accumulation of metabolites associated with specific gene defects. Here we review the potential roles of such " oncometabolites" in tumor evolution and as clinical biomarkers for the detection of cancers characterized by metabolic dysregulation.

Original languageEnglish
Pages (from-to)3652-3658
Number of pages7
JournalJournal of Clinical Investigation
Volume123
Issue number9
DOIs
Publication statusPublished - 2013 Sep 3

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Neoplasms
Tumor Biomarkers
Genes
Mass Spectrometry
Magnetic Resonance Spectroscopy
Technology
Mutation
Enzymes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Oncometabolites : Linking altered metabolism with cancer. / Yang, Ming; Soga, Tomoyoshi; Pollard, Patrick J.

In: Journal of Clinical Investigation, Vol. 123, No. 9, 03.09.2013, p. 3652-3658.

Research output: Contribution to journalArticle

Yang, Ming ; Soga, Tomoyoshi ; Pollard, Patrick J. / Oncometabolites : Linking altered metabolism with cancer. In: Journal of Clinical Investigation. 2013 ; Vol. 123, No. 9. pp. 3652-3658.
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