Oncometabolites: Linking altered metabolism with cancer

Ming Yang, Tomoyoshi Soga, Patrick J. Pollard

Research output: Contribution to journalReview article

173 Citations (Scopus)

Abstract

The discovery of cancer-associated mutations in genes encoding key metabolic enzymes has provided a direct link between altered metabolism and cancer. Advances in mass spectrometry and nuclear magnetic resonance technologies have facilitated high-resolution metabolite profiling of cells and tumors and identified the accumulation of metabolites associated with specific gene defects. Here we review the potential roles of such " oncometabolites" in tumor evolution and as clinical biomarkers for the detection of cancers characterized by metabolic dysregulation.

Original languageEnglish
Pages (from-to)3652-3658
Number of pages7
JournalJournal of Clinical Investigation
Volume123
Issue number9
DOIs
Publication statusPublished - 2013 Sep 3

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Oncometabolites: Linking altered metabolism with cancer'. Together they form a unique fingerprint.

  • Cite this