One-year eGFR decline rate is a good predictor of prognosis of renal failure in patients with type 2 diabetes

Jun Nojima, Shu Meguro, Naoto Ohkawa, Michiaki Furukoshi, Toshihide Kawai, Hiroshi Itoh

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

It is difficult to distinguish the onset of renal function decline from the typical variation in estimated glomerular filtration rate (eGFR) measurements in clinical practice. In this study, we used data analysis incorporating smoothing techniques to identify significant trends despite large amounts of noise. We identified the starting points of meaningful eGFR decline based on eGFR trajectories. This was a retrospective observational study of 2533 type 2 diabetes patients. We calculated 1-year eGFR decline rates from the difference between each eGFR value and that of the previous year. We examined the prediction capacity of 1-year eGFR decline rate for renal prognosis. When we performed receiver operating characteristic analysis, the area under the curve of 1-year eGFR decline rate was 0.963 (95% confidence interval: 0.953-0.973). With a cut-offvalue of more than 7.5% eGFR decline during a 1-year period, the sensitivity was 98.8% and specificity was 82.3%. The predictive accuracy of 1-year eGFR decline rate for renal prognosis was high.

Original languageEnglish
Pages (from-to)746-754
Number of pages9
JournalProceedings of the Japan Academy Series B: Physical and Biological Sciences
Volume93
Issue number9
DOIs
Publication statusPublished - 2017 Jan 1

Fingerprint

glomerular filtration rate
prognosis
renal failure
Glomerular Filtration Rate
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
Renal Insufficiency
predictions
Kidney
kidneys
observational studies
renal function
ROC Curve
Area Under Curve
trajectories
Observational Studies
Noise
confidence interval
data analysis
Retrospective Studies

Keywords

  • Change in eGFR
  • Renal outcome
  • Type 2 diabetic nephropathy

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Physics and Astronomy(all)

Cite this

One-year eGFR decline rate is a good predictor of prognosis of renal failure in patients with type 2 diabetes. / Nojima, Jun; Meguro, Shu; Ohkawa, Naoto; Furukoshi, Michiaki; Kawai, Toshihide; Itoh, Hiroshi.

In: Proceedings of the Japan Academy Series B: Physical and Biological Sciences, Vol. 93, No. 9, 01.01.2017, p. 746-754.

Research output: Contribution to journalArticle

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