Opioid δ1 receptor antagonist 7-benzylidenenaltrexone as an effective resistance reverser for chloroquine-resistant Plasmodium chabaudi

Yoshinori Miyata; Hideaki Fujii; Yumiko Osa; Seiki Kobayashi; Tsutomu Takeuchi; Hiroshi Nagase

doi:10.1016/j.bmcl.2011.06.085

Opioid δ₁ receptor antagonist 7-benzylidenenaltrexone as an effective resistance reverser for chloroquine-resistant Plasmodium chabaudi

Yoshinori Miyata, Hideaki Fujii, Yumiko Osa, Seiki Kobayashi, Tsutomu Takeuchi, Hiroshi Nagase

Department of Infectious Diseases

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

We evaluated antimalarial and/or chloroquine-resistance reversing effects of five opioid receptor antagonists. Although none of the evaluated compounds showed antimalarial effects, some of them, especially the δ₁ receptor antagonist, 7-benzylidenenaltrexone (BNTX) exhibited potent chloroquine-resistance reversing effects in Plasmodium chabaudi.

Original language	English
Pages (from-to)	4710-4712
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	21
Issue number	16
DOIs	https://doi.org/10.1016/j.bmcl.2011.06.085
Publication status	Published - 2011 Aug 15

Keywords

Chloroquine-resistance
Malaria
Opioid
Plasmodium chabaudi
Resistance reversing effect

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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Opioid δ₁ receptor antagonist 7-benzylidenenaltrexone as an effective resistance reverser for chloroquine-resistant Plasmodium chabaudi. / Miyata, Yoshinori; Fujii, Hideaki; Osa, Yumiko; Kobayashi, Seiki; Takeuchi, Tsutomu; Nagase, Hiroshi.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 21, No. 16, 15.08.2011, p. 4710-4712.

Research output: Contribution to journal › Article › peer-review

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