Opioid δ1 receptor antagonist 7-benzylidenenaltrexone as an effective resistance reverser for chloroquine-resistant Plasmodium chabaudi

Yoshinori Miyata; Hideaki Fujii; Yumiko Osa; Seiki Kobayashi; Tsutomu Takeuchi; Hiroshi Nagase

doi:10.1016/j.bmcl.2011.06.085

Opioid δ₁ receptor antagonist 7-benzylidenenaltrexone as an effective resistance reverser for chloroquine-resistant Plasmodium chabaudi

Yoshinori Miyata, Hideaki Fujii, Yumiko Osa, Seiki Kobayashi, Tsutomu Takeuchi, Hiroshi Nagase

Department of Infectious Diseases

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

We evaluated antimalarial and/or chloroquine-resistance reversing effects of five opioid receptor antagonists. Although none of the evaluated compounds showed antimalarial effects, some of them, especially the δ₁ receptor antagonist, 7-benzylidenenaltrexone (BNTX) exhibited potent chloroquine-resistance reversing effects in Plasmodium chabaudi.

Original language	English
Pages (from-to)	4710-4712
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	21
Issue number	16
DOIs	https://doi.org/10.1016/j.bmcl.2011.06.085
Publication status	Published - 2011 Aug 15

Keywords

Chloroquine-resistance
Malaria
Opioid
Plasmodium chabaudi
Resistance reversing effect

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.bmcl.2011.06.085

Cite this

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abstract = "We evaluated antimalarial and/or chloroquine-resistance reversing effects of five opioid receptor antagonists. Although none of the evaluated compounds showed antimalarial effects, some of them, especially the δ1 receptor antagonist, 7-benzylidenenaltrexone (BNTX) exhibited potent chloroquine-resistance reversing effects in Plasmodium chabaudi.",

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AU - Miyata, Yoshinori

AU - Fujii, Hideaki

AU - Osa, Yumiko

AU - Kobayashi, Seiki

AU - Takeuchi, Tsutomu

AU - Nagase, Hiroshi

PY - 2011/8/15

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KW - Chloroquine-resistance

KW - Malaria

KW - Opioid

KW - Plasmodium chabaudi

KW - Resistance reversing effect

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