Abstract
We evaluated antimalarial and/or chloroquine-resistance reversing effects of five opioid receptor antagonists. Although none of the evaluated compounds showed antimalarial effects, some of them, especially the δ1 receptor antagonist, 7-benzylidenenaltrexone (BNTX) exhibited potent chloroquine-resistance reversing effects in Plasmodium chabaudi.
Original language | English |
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Pages (from-to) | 4710-4712 |
Number of pages | 3 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 21 |
Issue number | 16 |
DOIs | |
Publication status | Published - 2011 Aug 15 |
Keywords
- Chloroquine-resistance
- Malaria
- Opioid
- Plasmodium chabaudi
- Resistance reversing effect
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry