Opioid δ1 receptor antagonist 7-benzylidenenaltrexone as an effective resistance reverser for chloroquine-resistant Plasmodium chabaudi

Yoshinori Miyata, Hideaki Fujii, Yumiko Osa, Seiki Kobayashi, Tsutomu Takeuchi, Hiroshi Nagase

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We evaluated antimalarial and/or chloroquine-resistance reversing effects of five opioid receptor antagonists. Although none of the evaluated compounds showed antimalarial effects, some of them, especially the δ1 receptor antagonist, 7-benzylidenenaltrexone (BNTX) exhibited potent chloroquine-resistance reversing effects in Plasmodium chabaudi.

Original languageEnglish
Pages (from-to)4710-4712
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume21
Issue number16
DOIs
Publication statusPublished - 2011 Aug 15

Keywords

  • Chloroquine-resistance
  • Malaria
  • Opioid
  • Plasmodium chabaudi
  • Resistance reversing effect

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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