Opioid modulation of vasopressin secretion in conscious rats

Takayuki Yamada, Kazuwa Nakao, Hiroshi Itoh, Gotaro Shirakami, Akira Sugawara, Yoshihiko Saito, Masashi Mukoyama, Hiroshi Arai, Kiminori Hosoda, Narito Morii, Shozo Shiono, Hiroo Imura

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

To clarify the role of endogenous opioid peptides in the control of vasopressin (AVP) secretion, the effects of an endogenous k-agonist, leumorphin, derived from proenkephalin B and an opioid antagonist, naloxone, on AVP secretion were examined in conscious and freely moving rats. Intraperitoneal injection of nicotine markedly increased AVP secretion in rats. The nicotineinduced AVP secretion was significantly suppressed by intracerebroventricular (i.c.v.) pretreatment with leumorphin. Intravenous injection of naloxone significantly increased the basal AVP level and carbachol-induced AVP secretion. These results indicate that endogenous opioid peptides have an inhibitory effect on AVP secretion in rats.

Original languageEnglish
Pages (from-to)361-367
Number of pages7
JournalClinical and Experimental Hypertension
VolumeA10
Issue numberS1
DOIs
Publication statusPublished - 1988
Externally publishedYes

Fingerprint

Vasopressins
Opioid Analgesics
Opioid Peptides
Naloxone
Narcotic Antagonists
Carbachol
Intraperitoneal Injections
Nicotine
Intravenous Injections
preproenkephalin

Keywords

  • Blood pressure
  • Carbachol
  • Heart rate
  • Leumorphin
  • Naloxone Nicotine
  • Opioid peptide
  • Vasopressin

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

Cite this

Yamada, T., Nakao, K., Itoh, H., Shirakami, G., Sugawara, A., Saito, Y., ... Imura, H. (1988). Opioid modulation of vasopressin secretion in conscious rats. Clinical and Experimental Hypertension, A10(S1), 361-367. https://doi.org/10.3109/10641968809075991

Opioid modulation of vasopressin secretion in conscious rats. / Yamada, Takayuki; Nakao, Kazuwa; Itoh, Hiroshi; Shirakami, Gotaro; Sugawara, Akira; Saito, Yoshihiko; Mukoyama, Masashi; Arai, Hiroshi; Hosoda, Kiminori; Morii, Narito; Shiono, Shozo; Imura, Hiroo.

In: Clinical and Experimental Hypertension, Vol. A10, No. S1, 1988, p. 361-367.

Research output: Contribution to journalArticle

Yamada, T, Nakao, K, Itoh, H, Shirakami, G, Sugawara, A, Saito, Y, Mukoyama, M, Arai, H, Hosoda, K, Morii, N, Shiono, S & Imura, H 1988, 'Opioid modulation of vasopressin secretion in conscious rats', Clinical and Experimental Hypertension, vol. A10, no. S1, pp. 361-367. https://doi.org/10.3109/10641968809075991
Yamada, Takayuki ; Nakao, Kazuwa ; Itoh, Hiroshi ; Shirakami, Gotaro ; Sugawara, Akira ; Saito, Yoshihiko ; Mukoyama, Masashi ; Arai, Hiroshi ; Hosoda, Kiminori ; Morii, Narito ; Shiono, Shozo ; Imura, Hiroo. / Opioid modulation of vasopressin secretion in conscious rats. In: Clinical and Experimental Hypertension. 1988 ; Vol. A10, No. S1. pp. 361-367.
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