TY - JOUR
T1 - Optic nerve involvement of Waldenström's macroglobulinemia
T2 - With autopsy findings
AU - Nishida, Hiroko
AU - Hashida, Risa
AU - Hatano, Mami
AU - Hori, Masao
AU - Obara, Katsuyuki
N1 - Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2014/8
Y1 - 2014/8
N2 - Waldenström's macroglobulinemia (WM) is an indolent chronic lymphoproliferative disorder within the spectrum of lymphoplasmacytic lymphoma (LPL), characterized by a proliferation of plasmacytoid lymphocytes and the production of monoclonal IgM. Although, peripheral neurologic complications commonly occurs due to hyperviscosity in WM, central nervous system (CNS) involvement is very rare. Herein, we present the case of a 67-year-old man who initially presented with progressive visual loss and was diagnosed as WM/LPL with a very aggressive clinical course. He underwent chemotherapy with high dose methotrexate (MTX) plus cytarabine (Ara-C). However, he died and findings of a subsequent autopsy revealed the presence of lymphoplasmacytoid cells in the optic nerve.
AB - Waldenström's macroglobulinemia (WM) is an indolent chronic lymphoproliferative disorder within the spectrum of lymphoplasmacytic lymphoma (LPL), characterized by a proliferation of plasmacytoid lymphocytes and the production of monoclonal IgM. Although, peripheral neurologic complications commonly occurs due to hyperviscosity in WM, central nervous system (CNS) involvement is very rare. Herein, we present the case of a 67-year-old man who initially presented with progressive visual loss and was diagnosed as WM/LPL with a very aggressive clinical course. He underwent chemotherapy with high dose methotrexate (MTX) plus cytarabine (Ara-C). However, he died and findings of a subsequent autopsy revealed the presence of lymphoplasmacytoid cells in the optic nerve.
KW - Autopsy
KW - Lymphoplasmacytic lymphoma
KW - Optic nerve
KW - Visual loss
KW - Waldenström's macroglobulinemia
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U2 - 10.1007/s10072-014-1865-7
DO - 10.1007/s10072-014-1865-7
M3 - Article
C2 - 25027010
AN - SCOPUS:84905123759
VL - 35
SP - 1299
EP - 1302
JO - Italian Journal of Neurological Sciences
JF - Italian Journal of Neurological Sciences
SN - 1590-1874
IS - 8
ER -
