Optic nerve involvement of Waldenström's macroglobulinemia: With autopsy findings

Hiroko Nishida; Risa Hashida; Mami Hatano; Masao Hori; Katsuyuki Obara

doi:10.1007/s10072-014-1865-7

Optic nerve involvement of Waldenström's macroglobulinemia: With autopsy findings

Hiroko Nishida, Risa Hashida, Mami Hatano, Masao Hori, Katsuyuki Obara

Division of Diagnostic Pathology

Research output: Contribution to journal › Article

1 Citation (Scopus)

Abstract

Waldenström's macroglobulinemia (WM) is an indolent chronic lymphoproliferative disorder within the spectrum of lymphoplasmacytic lymphoma (LPL), characterized by a proliferation of plasmacytoid lymphocytes and the production of monoclonal IgM. Although, peripheral neurologic complications commonly occurs due to hyperviscosity in WM, central nervous system (CNS) involvement is very rare. Herein, we present the case of a 67-year-old man who initially presented with progressive visual loss and was diagnosed as WM/LPL with a very aggressive clinical course. He underwent chemotherapy with high dose methotrexate (MTX) plus cytarabine (Ara-C). However, he died and findings of a subsequent autopsy revealed the presence of lymphoplasmacytoid cells in the optic nerve.

Original language	English
Pages (from-to)	1299-1302
Number of pages	4
Journal	Neurological Sciences
Volume	35
Issue number	8
DOIs	https://doi.org/10.1007/s10072-014-1865-7
Publication status	Published - 2014

Keywords

Autopsy
Lymphoplasmacytic lymphoma
Optic nerve
Visual loss
Waldenström's macroglobulinemia

ASJC Scopus subject areas

Dermatology
Clinical Neurology
Psychiatry and Mental health

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Nishida, H., Hashida, R., Hatano, M., Hori, M., & Obara, K. (2014). Optic nerve involvement of Waldenström's macroglobulinemia: With autopsy findings. Neurological Sciences, 35(8), 1299-1302. https://doi.org/10.1007/s10072-014-1865-7

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abstract = "Waldenstr{\"o}m's macroglobulinemia (WM) is an indolent chronic lymphoproliferative disorder within the spectrum of lymphoplasmacytic lymphoma (LPL), characterized by a proliferation of plasmacytoid lymphocytes and the production of monoclonal IgM. Although, peripheral neurologic complications commonly occurs due to hyperviscosity in WM, central nervous system (CNS) involvement is very rare. Herein, we present the case of a 67-year-old man who initially presented with progressive visual loss and was diagnosed as WM/LPL with a very aggressive clinical course. He underwent chemotherapy with high dose methotrexate (MTX) plus cytarabine (Ara-C). However, he died and findings of a subsequent autopsy revealed the presence of lymphoplasmacytoid cells in the optic nerve.",

keywords = "Autopsy, Lymphoplasmacytic lymphoma, Optic nerve, Visual loss, Waldenstr{\"o}m's macroglobulinemia",

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T1 - Optic nerve involvement of Waldenström's macroglobulinemia

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AU - Nishida, Hiroko

AU - Hashida, Risa

AU - Hatano, Mami

AU - Hori, Masao

AU - Obara, Katsuyuki

PY - 2014

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N2 - Waldenström's macroglobulinemia (WM) is an indolent chronic lymphoproliferative disorder within the spectrum of lymphoplasmacytic lymphoma (LPL), characterized by a proliferation of plasmacytoid lymphocytes and the production of monoclonal IgM. Although, peripheral neurologic complications commonly occurs due to hyperviscosity in WM, central nervous system (CNS) involvement is very rare. Herein, we present the case of a 67-year-old man who initially presented with progressive visual loss and was diagnosed as WM/LPL with a very aggressive clinical course. He underwent chemotherapy with high dose methotrexate (MTX) plus cytarabine (Ara-C). However, he died and findings of a subsequent autopsy revealed the presence of lymphoplasmacytoid cells in the optic nerve.

AB - Waldenström's macroglobulinemia (WM) is an indolent chronic lymphoproliferative disorder within the spectrum of lymphoplasmacytic lymphoma (LPL), characterized by a proliferation of plasmacytoid lymphocytes and the production of monoclonal IgM. Although, peripheral neurologic complications commonly occurs due to hyperviscosity in WM, central nervous system (CNS) involvement is very rare. Herein, we present the case of a 67-year-old man who initially presented with progressive visual loss and was diagnosed as WM/LPL with a very aggressive clinical course. He underwent chemotherapy with high dose methotrexate (MTX) plus cytarabine (Ara-C). However, he died and findings of a subsequent autopsy revealed the presence of lymphoplasmacytoid cells in the optic nerve.

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