Abstract
Waldenström's macroglobulinemia (WM) is an indolent chronic lymphoproliferative disorder within the spectrum of lymphoplasmacytic lymphoma (LPL), characterized by a proliferation of plasmacytoid lymphocytes and the production of monoclonal IgM. Although, peripheral neurologic complications commonly occurs due to hyperviscosity in WM, central nervous system (CNS) involvement is very rare. Herein, we present the case of a 67-year-old man who initially presented with progressive visual loss and was diagnosed as WM/LPL with a very aggressive clinical course. He underwent chemotherapy with high dose methotrexate (MTX) plus cytarabine (Ara-C). However, he died and findings of a subsequent autopsy revealed the presence of lymphoplasmacytoid cells in the optic nerve.
| Original language | English |
|---|---|
| Pages (from-to) | 1299-1302 |
| Number of pages | 4 |
| Journal | Neurological Sciences |
| Volume | 35 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- Autopsy
- Lymphoplasmacytic lymphoma
- Optic nerve
- Visual loss
- Waldenström's macroglobulinemia
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health
- Dermatology
- Medicine(all)
Cite this
Optic nerve involvement of Waldenström's macroglobulinemia : With autopsy findings. / Nishida, Hiroko; Hashida, Risa; Hatano, Mami; Hori, Masao; Obara, Katsuyuki.
In: Neurological Sciences, Vol. 35, No. 8, 2014, p. 1299-1302.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Optic nerve involvement of Waldenström's macroglobulinemia
T2 - With autopsy findings
AU - Nishida, Hiroko
AU - Hashida, Risa
AU - Hatano, Mami
AU - Hori, Masao
AU - Obara, Katsuyuki
PY - 2014
Y1 - 2014
N2 - Waldenström's macroglobulinemia (WM) is an indolent chronic lymphoproliferative disorder within the spectrum of lymphoplasmacytic lymphoma (LPL), characterized by a proliferation of plasmacytoid lymphocytes and the production of monoclonal IgM. Although, peripheral neurologic complications commonly occurs due to hyperviscosity in WM, central nervous system (CNS) involvement is very rare. Herein, we present the case of a 67-year-old man who initially presented with progressive visual loss and was diagnosed as WM/LPL with a very aggressive clinical course. He underwent chemotherapy with high dose methotrexate (MTX) plus cytarabine (Ara-C). However, he died and findings of a subsequent autopsy revealed the presence of lymphoplasmacytoid cells in the optic nerve.
AB - Waldenström's macroglobulinemia (WM) is an indolent chronic lymphoproliferative disorder within the spectrum of lymphoplasmacytic lymphoma (LPL), characterized by a proliferation of plasmacytoid lymphocytes and the production of monoclonal IgM. Although, peripheral neurologic complications commonly occurs due to hyperviscosity in WM, central nervous system (CNS) involvement is very rare. Herein, we present the case of a 67-year-old man who initially presented with progressive visual loss and was diagnosed as WM/LPL with a very aggressive clinical course. He underwent chemotherapy with high dose methotrexate (MTX) plus cytarabine (Ara-C). However, he died and findings of a subsequent autopsy revealed the presence of lymphoplasmacytoid cells in the optic nerve.
KW - Autopsy
KW - Lymphoplasmacytic lymphoma
KW - Optic nerve
KW - Visual loss
KW - Waldenström's macroglobulinemia
UR - http://www.scopus.com/inward/record.url?scp=84905123759&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84905123759&partnerID=8YFLogxK
U2 - 10.1007/s10072-014-1865-7
DO - 10.1007/s10072-014-1865-7
M3 - Article
C2 - 25027010
AN - SCOPUS:84905123759
VL - 35
SP - 1299
EP - 1302
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 8
ER -