Optic nerve seeding of atypical meningiomas presenting with subacute visual loss

2 case reports with genetic characterization

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Meningiomas rarely cause CSF dissemination, and CSF seeding to the optic nerve (ON) is extremely rare. This is the first report of 2 cases of atypical meningioma with subacute visual loss due to ON seeding. The authors present the genetic characteristics of these atypical meningiomas with CSF dissemination. The patient in Case 1 was a 36-year-old woman with a 1.5-cm mass within the left ON, and the patient in Case 2 was a 70-year-old woman with a 0.9-cm mass around the right ON. Both individuals had undergone multiple surgeries for primary lesions and local recurrent lesions. They presented with subacute visual loss, and both tumors were completely resected. The pathological diagnosis was atypical meningioma with high MIB-1 indices and p53-positive cell ratios in each case. Comparative genomic hybridization showed significant chromosomal copy number alterations similar to the results of previous surgeries, confirming that the tumors were disseminated lesions. The present findings suggest that genetic characteristics, such as 1p and 10qcen-23 losses and 17q and 20 gains, shared by the 2 cases might be associated with CSF dissemination of meningiomas.

Original languageEnglish
Pages (from-to)494-498
Number of pages5
JournalJournal of Neurosurgery
Volume119
Issue number2
DOIs
Publication statusPublished - 2013 Aug

Fingerprint

Meningioma
Optic Nerve
Comparative Genomic Hybridization
Neoplasms

Keywords

  • Atypical meningioma
  • Cerebrospinal fluid seeding
  • Comparative genomic hybridization
  • Dissemination
  • Oncology
  • Optic nerve

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

@article{1768847da4fc4fd09ee5efd9a9c9e4f9,
title = "Optic nerve seeding of atypical meningiomas presenting with subacute visual loss: 2 case reports with genetic characterization",
abstract = "Meningiomas rarely cause CSF dissemination, and CSF seeding to the optic nerve (ON) is extremely rare. This is the first report of 2 cases of atypical meningioma with subacute visual loss due to ON seeding. The authors present the genetic characteristics of these atypical meningiomas with CSF dissemination. The patient in Case 1 was a 36-year-old woman with a 1.5-cm mass within the left ON, and the patient in Case 2 was a 70-year-old woman with a 0.9-cm mass around the right ON. Both individuals had undergone multiple surgeries for primary lesions and local recurrent lesions. They presented with subacute visual loss, and both tumors were completely resected. The pathological diagnosis was atypical meningioma with high MIB-1 indices and p53-positive cell ratios in each case. Comparative genomic hybridization showed significant chromosomal copy number alterations similar to the results of previous surgeries, confirming that the tumors were disseminated lesions. The present findings suggest that genetic characteristics, such as 1p and 10qcen-23 losses and 17q and 20 gains, shared by the 2 cases might be associated with CSF dissemination of meningiomas.",
keywords = "Atypical meningioma, Cerebrospinal fluid seeding, Comparative genomic hybridization, Dissemination, Oncology, Optic nerve",
author = "Yohei Kitamura and Takenori Akiyama and Hikaru Sasaki and Yuichiro Hayashi and Kazunari Yoshida",
year = "2013",
month = "8",
doi = "10.3171/2013.1.JNS121533",
language = "English",
volume = "119",
pages = "494--498",
journal = "Journal of Neurosurgery",
issn = "0022-3085",
publisher = "American Association of Neurological Surgeons",
number = "2",

}

TY - JOUR

T1 - Optic nerve seeding of atypical meningiomas presenting with subacute visual loss

T2 - 2 case reports with genetic characterization

AU - Kitamura, Yohei

AU - Akiyama, Takenori

AU - Sasaki, Hikaru

AU - Hayashi, Yuichiro

AU - Yoshida, Kazunari

PY - 2013/8

Y1 - 2013/8

N2 - Meningiomas rarely cause CSF dissemination, and CSF seeding to the optic nerve (ON) is extremely rare. This is the first report of 2 cases of atypical meningioma with subacute visual loss due to ON seeding. The authors present the genetic characteristics of these atypical meningiomas with CSF dissemination. The patient in Case 1 was a 36-year-old woman with a 1.5-cm mass within the left ON, and the patient in Case 2 was a 70-year-old woman with a 0.9-cm mass around the right ON. Both individuals had undergone multiple surgeries for primary lesions and local recurrent lesions. They presented with subacute visual loss, and both tumors were completely resected. The pathological diagnosis was atypical meningioma with high MIB-1 indices and p53-positive cell ratios in each case. Comparative genomic hybridization showed significant chromosomal copy number alterations similar to the results of previous surgeries, confirming that the tumors were disseminated lesions. The present findings suggest that genetic characteristics, such as 1p and 10qcen-23 losses and 17q and 20 gains, shared by the 2 cases might be associated with CSF dissemination of meningiomas.

AB - Meningiomas rarely cause CSF dissemination, and CSF seeding to the optic nerve (ON) is extremely rare. This is the first report of 2 cases of atypical meningioma with subacute visual loss due to ON seeding. The authors present the genetic characteristics of these atypical meningiomas with CSF dissemination. The patient in Case 1 was a 36-year-old woman with a 1.5-cm mass within the left ON, and the patient in Case 2 was a 70-year-old woman with a 0.9-cm mass around the right ON. Both individuals had undergone multiple surgeries for primary lesions and local recurrent lesions. They presented with subacute visual loss, and both tumors were completely resected. The pathological diagnosis was atypical meningioma with high MIB-1 indices and p53-positive cell ratios in each case. Comparative genomic hybridization showed significant chromosomal copy number alterations similar to the results of previous surgeries, confirming that the tumors were disseminated lesions. The present findings suggest that genetic characteristics, such as 1p and 10qcen-23 losses and 17q and 20 gains, shared by the 2 cases might be associated with CSF dissemination of meningiomas.

KW - Atypical meningioma

KW - Cerebrospinal fluid seeding

KW - Comparative genomic hybridization

KW - Dissemination

KW - Oncology

KW - Optic nerve

UR - http://www.scopus.com/inward/record.url?scp=84881165848&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84881165848&partnerID=8YFLogxK

U2 - 10.3171/2013.1.JNS121533

DO - 10.3171/2013.1.JNS121533

M3 - Article

VL - 119

SP - 494

EP - 498

JO - Journal of Neurosurgery

JF - Journal of Neurosurgery

SN - 0022-3085

IS - 2

ER -