Optical characteristics of human skin with hyperpigmentation caused by fluorinated pyrimidine anticancer agent

Takahiro Kono, Nobuaki Imanishi, Keiko Nozawa, Atsuo Takashima, Rajagopalan Uma Maheswari, Hiroki Gonome, Jun Yamada

Research output: Contribution to journalArticle

Abstract

The fluorinated pyrimidine anticancer agent has several side effects that degrade the quality of life of patients, including hyperpigmentation. Hyperpigmentation differs in color from common pigmentation such as a suntan, giving rise to dramatic skin appearance changes. In this study, we measured the optical properties of the skin of patients with hyperpigmentation by using the reflection spatial profile method (RSPM). The absorption coefficient in hyperpigmentation increased ~1.5–2.5 times and pheomelanin significantly increased compared to the normal skin. In addition, the scattering coefficient of skin with hyperpigmentation was about 65.9–76.5% of that of normal skin.

Original languageEnglish
Article number366571
Pages (from-to)3747-3759
Number of pages13
JournalBiomedical Optics Express
Volume10
Issue number8
DOIs
Publication statusPublished - 2019 Aug 1

Fingerprint

Hyperpigmentation
pyrimidines
Antineoplastic Agents
Skin
scattering coefficients
absorptivity
Suntan
color
optical properties
Pigmentation
Color
Quality of Life
pyrimidine

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

Cite this

Optical characteristics of human skin with hyperpigmentation caused by fluorinated pyrimidine anticancer agent. / Kono, Takahiro; Imanishi, Nobuaki; Nozawa, Keiko; Takashima, Atsuo; Maheswari, Rajagopalan Uma; Gonome, Hiroki; Yamada, Jun.

In: Biomedical Optics Express, Vol. 10, No. 8, 366571, 01.08.2019, p. 3747-3759.

Research output: Contribution to journalArticle

Kono, Takahiro ; Imanishi, Nobuaki ; Nozawa, Keiko ; Takashima, Atsuo ; Maheswari, Rajagopalan Uma ; Gonome, Hiroki ; Yamada, Jun. / Optical characteristics of human skin with hyperpigmentation caused by fluorinated pyrimidine anticancer agent. In: Biomedical Optics Express. 2019 ; Vol. 10, No. 8. pp. 3747-3759.
@article{eb37357b4e444456923c7feb4575d8e6,
title = "Optical characteristics of human skin with hyperpigmentation caused by fluorinated pyrimidine anticancer agent",
abstract = "The fluorinated pyrimidine anticancer agent has several side effects that degrade the quality of life of patients, including hyperpigmentation. Hyperpigmentation differs in color from common pigmentation such as a suntan, giving rise to dramatic skin appearance changes. In this study, we measured the optical properties of the skin of patients with hyperpigmentation by using the reflection spatial profile method (RSPM). The absorption coefficient in hyperpigmentation increased ~1.5–2.5 times and pheomelanin significantly increased compared to the normal skin. In addition, the scattering coefficient of skin with hyperpigmentation was about 65.9–76.5{\%} of that of normal skin.",
author = "Takahiro Kono and Nobuaki Imanishi and Keiko Nozawa and Atsuo Takashima and Maheswari, {Rajagopalan Uma} and Hiroki Gonome and Jun Yamada",
year = "2019",
month = "8",
day = "1",
doi = "10.1364/BOE.10.003747",
language = "English",
volume = "10",
pages = "3747--3759",
journal = "Biomedical Optics Express",
issn = "2156-7085",
publisher = "The Optical Society",
number = "8",

}

TY - JOUR

T1 - Optical characteristics of human skin with hyperpigmentation caused by fluorinated pyrimidine anticancer agent

AU - Kono, Takahiro

AU - Imanishi, Nobuaki

AU - Nozawa, Keiko

AU - Takashima, Atsuo

AU - Maheswari, Rajagopalan Uma

AU - Gonome, Hiroki

AU - Yamada, Jun

PY - 2019/8/1

Y1 - 2019/8/1

N2 - The fluorinated pyrimidine anticancer agent has several side effects that degrade the quality of life of patients, including hyperpigmentation. Hyperpigmentation differs in color from common pigmentation such as a suntan, giving rise to dramatic skin appearance changes. In this study, we measured the optical properties of the skin of patients with hyperpigmentation by using the reflection spatial profile method (RSPM). The absorption coefficient in hyperpigmentation increased ~1.5–2.5 times and pheomelanin significantly increased compared to the normal skin. In addition, the scattering coefficient of skin with hyperpigmentation was about 65.9–76.5% of that of normal skin.

AB - The fluorinated pyrimidine anticancer agent has several side effects that degrade the quality of life of patients, including hyperpigmentation. Hyperpigmentation differs in color from common pigmentation such as a suntan, giving rise to dramatic skin appearance changes. In this study, we measured the optical properties of the skin of patients with hyperpigmentation by using the reflection spatial profile method (RSPM). The absorption coefficient in hyperpigmentation increased ~1.5–2.5 times and pheomelanin significantly increased compared to the normal skin. In addition, the scattering coefficient of skin with hyperpigmentation was about 65.9–76.5% of that of normal skin.

UR - http://www.scopus.com/inward/record.url?scp=85070830459&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070830459&partnerID=8YFLogxK

U2 - 10.1364/BOE.10.003747

DO - 10.1364/BOE.10.003747

M3 - Article

VL - 10

SP - 3747

EP - 3759

JO - Biomedical Optics Express

JF - Biomedical Optics Express

SN - 2156-7085

IS - 8

M1 - 366571

ER -