Optical characteristics of human skin with hyperpigmentation caused by fluorinated pyrimidine anticancer agent

Takahiro Kono; Nobuaki Imanishi; Keiko Nozawa; Atsuo Takashima; Rajagopalan Uma Maheswari; Hiroki Gonome; Jun Yamada

doi:10.1364/BOE.10.003747

Optical characteristics of human skin with hyperpigmentation caused by fluorinated pyrimidine anticancer agent

Takahiro Kono, Nobuaki Imanishi, Keiko Nozawa, Atsuo Takashima, Rajagopalan Uma Maheswari, Hiroki Gonome, Jun Yamada

Department of Anatomy

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The fluorinated pyrimidine anticancer agent has several side effects that degrade the quality of life of patients, including hyperpigmentation. Hyperpigmentation differs in color from common pigmentation such as a suntan, giving rise to dramatic skin appearance changes. In this study, we measured the optical properties of the skin of patients with hyperpigmentation by using the reflection spatial profile method (RSPM). The absorption coefficient in hyperpigmentation increased ~1.5–2.5 times and pheomelanin significantly increased compared to the normal skin. In addition, the scattering coefficient of skin with hyperpigmentation was about 65.9–76.5% of that of normal skin.

Original language	English
Article number	366571
Pages (from-to)	3747-3759
Number of pages	13
Journal	Biomedical Optics Express
Volume	10
Issue number	8
DOIs	https://doi.org/10.1364/BOE.10.003747
Publication status	Published - 2019 Aug 1

ASJC Scopus subject areas

Biotechnology
Atomic and Molecular Physics, and Optics

Access to Document

10.1364/BOE.10.003747

Cite this

@article{eb37357b4e444456923c7feb4575d8e6,

title = "Optical characteristics of human skin with hyperpigmentation caused by fluorinated pyrimidine anticancer agent",

abstract = "The fluorinated pyrimidine anticancer agent has several side effects that degrade the quality of life of patients, including hyperpigmentation. Hyperpigmentation differs in color from common pigmentation such as a suntan, giving rise to dramatic skin appearance changes. In this study, we measured the optical properties of the skin of patients with hyperpigmentation by using the reflection spatial profile method (RSPM). The absorption coefficient in hyperpigmentation increased ~1.5–2.5 times and pheomelanin significantly increased compared to the normal skin. In addition, the scattering coefficient of skin with hyperpigmentation was about 65.9–76.5% of that of normal skin.",

author = "Takahiro Kono and Nobuaki Imanishi and Keiko Nozawa and Atsuo Takashima and Maheswari, {Rajagopalan Uma} and Hiroki Gonome and Jun Yamada",

note = "Publisher Copyright: {\textcopyright} 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.",

year = "2019",

month = aug,

day = "1",

doi = "10.1364/BOE.10.003747",

language = "English",

volume = "10",

pages = "3747--3759",

journal = "Biomedical Optics Express",

issn = "2156-7085",

publisher = "The Optical Society",

number = "8",

}

TY - JOUR

T1 - Optical characteristics of human skin with hyperpigmentation caused by fluorinated pyrimidine anticancer agent

AU - Kono, Takahiro

AU - Imanishi, Nobuaki

AU - Nozawa, Keiko

AU - Takashima, Atsuo

AU - Maheswari, Rajagopalan Uma

AU - Gonome, Hiroki

AU - Yamada, Jun

PY - 2019/8/1

Y1 - 2019/8/1

N2 - The fluorinated pyrimidine anticancer agent has several side effects that degrade the quality of life of patients, including hyperpigmentation. Hyperpigmentation differs in color from common pigmentation such as a suntan, giving rise to dramatic skin appearance changes. In this study, we measured the optical properties of the skin of patients with hyperpigmentation by using the reflection spatial profile method (RSPM). The absorption coefficient in hyperpigmentation increased ~1.5–2.5 times and pheomelanin significantly increased compared to the normal skin. In addition, the scattering coefficient of skin with hyperpigmentation was about 65.9–76.5% of that of normal skin.

AB - The fluorinated pyrimidine anticancer agent has several side effects that degrade the quality of life of patients, including hyperpigmentation. Hyperpigmentation differs in color from common pigmentation such as a suntan, giving rise to dramatic skin appearance changes. In this study, we measured the optical properties of the skin of patients with hyperpigmentation by using the reflection spatial profile method (RSPM). The absorption coefficient in hyperpigmentation increased ~1.5–2.5 times and pheomelanin significantly increased compared to the normal skin. In addition, the scattering coefficient of skin with hyperpigmentation was about 65.9–76.5% of that of normal skin.

UR - http://www.scopus.com/inward/record.url?scp=85070830459&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070830459&partnerID=8YFLogxK

U2 - 10.1364/BOE.10.003747

DO - 10.1364/BOE.10.003747

M3 - Article

AN - SCOPUS:85070830459

SN - 2156-7085

VL - 10

SP - 3747

EP - 3759

JO - Biomedical Optics Express

JF - Biomedical Optics Express

IS - 8

M1 - 366571

ER -

Optical characteristics of human skin with hyperpigmentation caused by fluorinated pyrimidine anticancer agent

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this