Optimal cytoreductive surgery in patients with advanced uterine carcinosarcoma: A multi-institutional retrospective study from the Japanese gynecologic oncology group

Kenichi Harano, Akihiro Hirakawa, Mayu Yunokawa, Toshiaki Nakamura, Toyomi Satoh, Tadaaki Nishikawa, Daisuke Aoki, Kimihiko Ito, Kiyoshi Ito, Toru Nakanishi, Nobuyuki Susumu, Kazuhiro Takehara, Yoh Watanabe, Hidemichi Watari, Toshiaki Saito

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Abstract

Background The benefits of cytoreductive surgery for uterine carcinosarcoma (UCS) are unknown. The objective of this study was to determine the impact of optimal surgery on advanced UCS patient survival. Methods We performed a multi-institutional, retrospective study of women diagnosed with stage III–IV UCS between 2007 and 2012. Data were obtained retrospectively from medical records, including demographic, clinicopathologic, treatment, and outcome information. Optimal cytoreductive surgery was defined as surgery resulting in a maximum residual tumor of ≤ 1 cm. The Kaplan-Meier method was used to calculate progression-free survival (PFS) and overall survival (OS), and the Cox regression model was used to examine the impact of selected factors on survival. Results A total of 225 UCS patients (median age, 63 years) were identified, including 136 (60%) with stage III and 89 (40%) with stage IV disease. Among these patients, 170 (76%) received optimal cytoreductive surgery. The median follow-up time was 19 months. The median PFS was 11.5 months (95% confidence interval [CI], 10.6–13.4) and 8.1 months (95% CI, 5.1–9.5) for patients who received optimal and suboptimal cytoreductive surgery, respectively (P < 0.0001). The median OS was 37.9 months (95% CI, 28.3–not reached) and 18 months (95% CI, 9.6–21) for patients who received optimal and suboptimal cytoreductive surgery, respectively (P < 0.0001). Residual tumor > 1 cm was associated with worse OS while pelvic lymph node dissection was associated with improved OS. Conclusion Optimal cytoreductive surgery and pelvic lymph node dissection are associated with improved OS in advanced UCS patients.

Original languageEnglish
Pages (from-to)447-453
Number of pages7
JournalGynecologic Oncology
Volume141
Issue number3
DOIs
Publication statusPublished - 2016 Jun

Keywords

  • Cytoreductive surgery
  • Pelvic lymph node dissection
  • Uterine carcinosarcoma

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

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    Harano, K., Hirakawa, A., Yunokawa, M., Nakamura, T., Satoh, T., Nishikawa, T., Aoki, D., Ito, K., Ito, K., Nakanishi, T., Susumu, N., Takehara, K., Watanabe, Y., Watari, H., & Saito, T. (2016). Optimal cytoreductive surgery in patients with advanced uterine carcinosarcoma: A multi-institutional retrospective study from the Japanese gynecologic oncology group. Gynecologic Oncology, 141(3), 447-453. https://doi.org/10.1016/j.ygyno.2016.04.004