Optimal sublobar resection for c-stage I non-small cell lung cancer: significance of margin distance to tumor size ratio and margin cytology (Supplementary analysis of KLSG-0801): complete republication

All the co-authors are members of Kan-Etsu Lung Cancer Study Group (KLSG)

Research output: Contribution to journalArticle

Abstract

Background: Sublobar resection for lung cancer is associated with a higher risk of recurrence than that of lobectomy; we evaluated the factors considered to be predictors of recurrence. Methods: By analyzing multicenter prospective studies of sublobar resection for patients with c-stage I non-small lung cancer who were unable to undergo lobectomy (KLSG-0801), we investigated the relationship between (1) tumor location (TL) and margin distance from the stump (MD), (2) the MD/tumor size (TS) ratio and prognosis, (3) and the margin cytology (MC) and prognosis. Results: The correlation between TS and MD was statistically significant in cases of easily resectable regions defined by Lewis’ classification (n = 18). However, there was no correlation in difficult-to-resect regions (n = 14). Among cases of recurrence, the MD/TS ratio was less than 1. The 3-year survival rate was 100% for patients with MD/TS > 1 (n = 12), 59.7% for patients with MD/TS ≤ 1 (n = 20) (p = 0.06), 88.1% in cases of negative MC (n = 18), and 20% in cases of positive MC (n = 5) (p = 0.001). Conclusion: Cases with positive MC had a significantly worse prognosis than those with negative MC. It may be difficult to secure an MD greater than the TS in a difficult-to-resect region according to Lewis’ classification.

Original languageEnglish
JournalGeneral Thoracic and Cardiovascular Surgery
DOIs
Publication statusPublished - 2019 Jan 1

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Non-Small Cell Lung Carcinoma
Cell Biology
Neoplasms
Recurrence
Lung Neoplasms
Multicenter Studies
Survival Rate
Prospective Studies

Keywords

  • Margin cytology
  • Margin distance
  • Non-small cell lung cancer
  • Stage I
  • Tumor size

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

@article{97d4cbd90d8044719ed63176b8c8b75c,
title = "Optimal sublobar resection for c-stage I non-small cell lung cancer: significance of margin distance to tumor size ratio and margin cytology (Supplementary analysis of KLSG-0801): complete republication",
abstract = "Background: Sublobar resection for lung cancer is associated with a higher risk of recurrence than that of lobectomy; we evaluated the factors considered to be predictors of recurrence. Methods: By analyzing multicenter prospective studies of sublobar resection for patients with c-stage I non-small lung cancer who were unable to undergo lobectomy (KLSG-0801), we investigated the relationship between (1) tumor location (TL) and margin distance from the stump (MD), (2) the MD/tumor size (TS) ratio and prognosis, (3) and the margin cytology (MC) and prognosis. Results: The correlation between TS and MD was statistically significant in cases of easily resectable regions defined by Lewis’ classification (n = 18). However, there was no correlation in difficult-to-resect regions (n = 14). Among cases of recurrence, the MD/TS ratio was less than 1. The 3-year survival rate was 100{\%} for patients with MD/TS > 1 (n = 12), 59.7{\%} for patients with MD/TS ≤ 1 (n = 20) (p = 0.06), 88.1{\%} in cases of negative MC (n = 18), and 20{\%} in cases of positive MC (n = 5) (p = 0.001). Conclusion: Cases with positive MC had a significantly worse prognosis than those with negative MC. It may be difficult to secure an MD greater than the TS in a difficult-to-resect region according to Lewis’ classification.",
keywords = "Margin cytology, Margin distance, Non-small cell lung cancer, Stage I, Tumor size",
author = "{All the co-authors are members of Kan-Etsu Lung Cancer Study Group (KLSG)} and Nobumasa Takahashi and Noriyoshi Sawabata and Masafumi Kawamura and Takashi Ohtsuka and Hirotoshi Horio and Hirozo Sakaguchi and Mitsuo Nakayama and Katsuo Yoshiya and Masayuki Chida and Eishin Hoshi",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s11748-019-01069-8",
language = "English",
journal = "General Thoracic and Cardiovascular Surgery",
issn = "1863-6705",
publisher = "Springer Japan",

}

TY - JOUR

T1 - Optimal sublobar resection for c-stage I non-small cell lung cancer

T2 - significance of margin distance to tumor size ratio and margin cytology (Supplementary analysis of KLSG-0801): complete republication

AU - All the co-authors are members of Kan-Etsu Lung Cancer Study Group (KLSG)

AU - Takahashi, Nobumasa

AU - Sawabata, Noriyoshi

AU - Kawamura, Masafumi

AU - Ohtsuka, Takashi

AU - Horio, Hirotoshi

AU - Sakaguchi, Hirozo

AU - Nakayama, Mitsuo

AU - Yoshiya, Katsuo

AU - Chida, Masayuki

AU - Hoshi, Eishin

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Sublobar resection for lung cancer is associated with a higher risk of recurrence than that of lobectomy; we evaluated the factors considered to be predictors of recurrence. Methods: By analyzing multicenter prospective studies of sublobar resection for patients with c-stage I non-small lung cancer who were unable to undergo lobectomy (KLSG-0801), we investigated the relationship between (1) tumor location (TL) and margin distance from the stump (MD), (2) the MD/tumor size (TS) ratio and prognosis, (3) and the margin cytology (MC) and prognosis. Results: The correlation between TS and MD was statistically significant in cases of easily resectable regions defined by Lewis’ classification (n = 18). However, there was no correlation in difficult-to-resect regions (n = 14). Among cases of recurrence, the MD/TS ratio was less than 1. The 3-year survival rate was 100% for patients with MD/TS > 1 (n = 12), 59.7% for patients with MD/TS ≤ 1 (n = 20) (p = 0.06), 88.1% in cases of negative MC (n = 18), and 20% in cases of positive MC (n = 5) (p = 0.001). Conclusion: Cases with positive MC had a significantly worse prognosis than those with negative MC. It may be difficult to secure an MD greater than the TS in a difficult-to-resect region according to Lewis’ classification.

AB - Background: Sublobar resection for lung cancer is associated with a higher risk of recurrence than that of lobectomy; we evaluated the factors considered to be predictors of recurrence. Methods: By analyzing multicenter prospective studies of sublobar resection for patients with c-stage I non-small lung cancer who were unable to undergo lobectomy (KLSG-0801), we investigated the relationship between (1) tumor location (TL) and margin distance from the stump (MD), (2) the MD/tumor size (TS) ratio and prognosis, (3) and the margin cytology (MC) and prognosis. Results: The correlation between TS and MD was statistically significant in cases of easily resectable regions defined by Lewis’ classification (n = 18). However, there was no correlation in difficult-to-resect regions (n = 14). Among cases of recurrence, the MD/TS ratio was less than 1. The 3-year survival rate was 100% for patients with MD/TS > 1 (n = 12), 59.7% for patients with MD/TS ≤ 1 (n = 20) (p = 0.06), 88.1% in cases of negative MC (n = 18), and 20% in cases of positive MC (n = 5) (p = 0.001). Conclusion: Cases with positive MC had a significantly worse prognosis than those with negative MC. It may be difficult to secure an MD greater than the TS in a difficult-to-resect region according to Lewis’ classification.

KW - Margin cytology

KW - Margin distance

KW - Non-small cell lung cancer

KW - Stage I

KW - Tumor size

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U2 - 10.1007/s11748-019-01069-8

DO - 10.1007/s11748-019-01069-8

M3 - Article

AN - SCOPUS:85061896960

JO - General Thoracic and Cardiovascular Surgery

JF - General Thoracic and Cardiovascular Surgery

SN - 1863-6705

ER -