Optogenetics research using the mouse as a model system

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Smooth progress in the field of optogenetic research can be, as the suffix ‘-genetics’ indicates, expected using biological models that provide conditions suitable for genetic control or gene manipulation. The artificial expression of opsin molecules is expected to be carried out smoothly in mice compared with rats or non-human primates because of established inheritable genetic modification technologies in this species. However, when compared with the nematode or the fly, there are still many difficulties in the expression of opsin in mice if flexible gene manipulation is attempted.

Original languageEnglish
Title of host publicationOptogenetics: Light-Sensing Proteins and their Applications
PublisherSpringer Japan
Pages227-240
Number of pages14
ISBN (Electronic)9784431555162
ISBN (Print)9784431555155
DOIs
Publication statusPublished - 2015 Jan 1

Keywords

  • BAC transgenic
  • Cre-loxP system
  • KENGE-tet
  • Mouse genetics
  • Tet-system
  • β-actin gene

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Tanaka, K. (2015). Optogenetics research using the mouse as a model system. In Optogenetics: Light-Sensing Proteins and their Applications (pp. 227-240). Springer Japan. https://doi.org/10.1007/978-4-431-55516-2_15