Oral administration of royal jelly restores tear secretion capacity in rat blink-suppressed dry eye model by modulating lacrimal gland function

Toshihiro Imada, Shigeru Nakamura, Naoki Kitamura, Izumi Shibuya, Kazuo Tsubota

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Tears are secreted from the lacrimal gland (LG), a dysfunction in which induces dry eye, resulting in ocular discomfort and visual impairment. Honey bee products are used as a nutritional source in daily life and medicine; however, little is known about their effects on dry eye. The aim of the present study was to investigate the effects of honey bee products on tear secretion capacity in dry eye. We selected raw honey, propolis, royal jelly (RJ), pollen, or larva from commercially available honey bee products. Tear secretion capacity was evaluated following the oral administration of each honey bee product in a rat blink-suppressed dry eye model. Changes in tear secretion, LG ATP content, and LG mitochondrial levels were measured. RJ restored the tear secretion capacity and decrease in LG ATP content and mitochondrial levels to the largest extent. Royal jelly can be used as a preventative intervention for dry eye by managing tear secretion capacity in the LG.

Original languageEnglish
Article numbere106338
JournalPLoS One
Volume9
Issue number9
DOIs
Publication statusPublished - 2014 Sep 22

Fingerprint

lacrimal apparatus
royal jelly
Lacrimal Apparatus
Tears
Honey
oral administration
Oral Administration
Rats
eyes
Bees
secretion
honey bees
rats
Adenosine Triphosphate
Propolis
Medicine
propolis
Vision Disorders
Pollen
honey

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Oral administration of royal jelly restores tear secretion capacity in rat blink-suppressed dry eye model by modulating lacrimal gland function. / Imada, Toshihiro; Nakamura, Shigeru; Kitamura, Naoki; Shibuya, Izumi; Tsubota, Kazuo.

In: PLoS One, Vol. 9, No. 9, e106338, 22.09.2014.

Research output: Contribution to journalArticle

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