Abstract
We examined the transfer of levofloxacin (LVFX) into serum, gingiva, dental follicles, and mandibular bone following oral administration of a single 500 mg dose of LVFX to 10 subjects, comprising 3 males and 7 females. The mean concentrations 2.0 to 4.5 h after administration in serum, gingiva, dental follicles, and mandibular bone were 4.85 ± 0.82 μg/mL, 7.76 ± 3.21, 7.38 ± 2.04 μg/g, and 2.90 ± 1.94, respectively. The mean ratios of concentrations in gingiva/serum, dental follicle/serum, and mandibular bone/serum were 1.58 ± 0.53, 1.54 ± 0.50, and 0.59 ± 0.35, respectively. The mean LVFX concentrations in gingival tissue, dental follicles and mandibular bone exceeded the MIC for 90% of clinically isolated oral strains of streptococci and most of the anaerobic bacteria. These results indicated that LVFX penetrated well into oral and maxillofacial tissue and that LVFX 500 mg q.d. treatment was as effective as, or more effective than, 100 mg t.i.d. for the clinical treatment of oral infections.
| Original language | English |
|---|---|
| Pages (from-to) | 643-645 |
| Number of pages | 3 |
| Journal | Japanese Journal of Chemotherapy |
| Volume | 60 |
| Issue number | 6 |
| Publication status | Published - 2012 Nov |
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Keywords
- Levofloxacin
- Mandible
- Oral tissue
- Tissue penetration
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
Cite this
Oral and maxillofacial tissue penetration of levofloxacin following oral administration of a single 500 mg dose. / Asoda, Seiji; Iwasaki, Ryotaro; Fukaya, Chie; Hosaka, Yasuo; Usuda, Shin; Kawana, Hiromasa; Nakagawa, Taneaki.
In: Japanese Journal of Chemotherapy, Vol. 60, No. 6, 11.2012, p. 643-645.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Oral and maxillofacial tissue penetration of levofloxacin following oral administration of a single 500 mg dose
AU - Asoda, Seiji
AU - Iwasaki, Ryotaro
AU - Fukaya, Chie
AU - Hosaka, Yasuo
AU - Usuda, Shin
AU - Kawana, Hiromasa
AU - Nakagawa, Taneaki
PY - 2012/11
Y1 - 2012/11
N2 - We examined the transfer of levofloxacin (LVFX) into serum, gingiva, dental follicles, and mandibular bone following oral administration of a single 500 mg dose of LVFX to 10 subjects, comprising 3 males and 7 females. The mean concentrations 2.0 to 4.5 h after administration in serum, gingiva, dental follicles, and mandibular bone were 4.85 ± 0.82 μg/mL, 7.76 ± 3.21, 7.38 ± 2.04 μg/g, and 2.90 ± 1.94, respectively. The mean ratios of concentrations in gingiva/serum, dental follicle/serum, and mandibular bone/serum were 1.58 ± 0.53, 1.54 ± 0.50, and 0.59 ± 0.35, respectively. The mean LVFX concentrations in gingival tissue, dental follicles and mandibular bone exceeded the MIC for 90% of clinically isolated oral strains of streptococci and most of the anaerobic bacteria. These results indicated that LVFX penetrated well into oral and maxillofacial tissue and that LVFX 500 mg q.d. treatment was as effective as, or more effective than, 100 mg t.i.d. for the clinical treatment of oral infections.
AB - We examined the transfer of levofloxacin (LVFX) into serum, gingiva, dental follicles, and mandibular bone following oral administration of a single 500 mg dose of LVFX to 10 subjects, comprising 3 males and 7 females. The mean concentrations 2.0 to 4.5 h after administration in serum, gingiva, dental follicles, and mandibular bone were 4.85 ± 0.82 μg/mL, 7.76 ± 3.21, 7.38 ± 2.04 μg/g, and 2.90 ± 1.94, respectively. The mean ratios of concentrations in gingiva/serum, dental follicle/serum, and mandibular bone/serum were 1.58 ± 0.53, 1.54 ± 0.50, and 0.59 ± 0.35, respectively. The mean LVFX concentrations in gingival tissue, dental follicles and mandibular bone exceeded the MIC for 90% of clinically isolated oral strains of streptococci and most of the anaerobic bacteria. These results indicated that LVFX penetrated well into oral and maxillofacial tissue and that LVFX 500 mg q.d. treatment was as effective as, or more effective than, 100 mg t.i.d. for the clinical treatment of oral infections.
KW - Levofloxacin
KW - Mandible
KW - Oral tissue
KW - Tissue penetration
UR - http://www.scopus.com/inward/record.url?scp=84870887276&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84870887276&partnerID=8YFLogxK
M3 - Article
VL - 60
SP - 643
EP - 645
JO - Japanese Journal of Chemotherapy
JF - Japanese Journal of Chemotherapy
SN - 1340-7007
IS - 6
ER -