TY - JOUR
T1 - Oral consumption of α-glucosyl-hesperidin could prevent lens hardening, which causes presbyopia
AU - Nakazawa, Yosuke
AU - Aoki, Miki
AU - Doki, Yuri
AU - Morishita, Naoki
AU - Endo, Shin
AU - Nagai, Noriaki
AU - Funakoshi-Tago, Megumi
AU - Tamura, Hiroomi
N1 - Funding Information:
This work was supported by grants from the Keio Gijuku Fukuzawa Memorial Fund for the Advancement of Education, Research and from the Japan Health Foundation, and the Japan Society for the Promotion of Science KAKENHI [grants numbers 20K07184 ] to Y.N.
PY - 2021/3
Y1 - 2021/3
N2 - Presbyopia is one of the most well-known diseases of the eye, predominantly affecting the adult population after 50 years’. Due to hardening of the lens and failure of accommodative change, patients lose the ability to focus on near objects. This eye symptom is reported to be an early symptom of age-related nuclear cataract, and we have previously reported that hesperetin treatment could delay the onset of nuclear cataractogenesis induced by sodium selenite. In this study, we examined whether oral intake of α-glucosyl-hesperidin (G-Hsd), which has greater water solubility than hesperetin, could delay the onset of presbyopia. G-Hsd treatment protected lens elasticity, upregulated the mRNA expression of anti-oxidative enzymes like glutathione reductase and thioredoxin reductase 1 in the plasma and lens, and prevented premature cataract symptoms in selenite-induced cataract rat lens. Thus, the anti-presbyopic effects of G-Hsd were attributed, at least in part, to its antioxidant effects. G-Hsd represents the first oral treatment agent with anti-presbyopia and/or anti-cataract properties.
AB - Presbyopia is one of the most well-known diseases of the eye, predominantly affecting the adult population after 50 years’. Due to hardening of the lens and failure of accommodative change, patients lose the ability to focus on near objects. This eye symptom is reported to be an early symptom of age-related nuclear cataract, and we have previously reported that hesperetin treatment could delay the onset of nuclear cataractogenesis induced by sodium selenite. In this study, we examined whether oral intake of α-glucosyl-hesperidin (G-Hsd), which has greater water solubility than hesperetin, could delay the onset of presbyopia. G-Hsd treatment protected lens elasticity, upregulated the mRNA expression of anti-oxidative enzymes like glutathione reductase and thioredoxin reductase 1 in the plasma and lens, and prevented premature cataract symptoms in selenite-induced cataract rat lens. Thus, the anti-presbyopic effects of G-Hsd were attributed, at least in part, to its antioxidant effects. G-Hsd represents the first oral treatment agent with anti-presbyopia and/or anti-cataract properties.
KW - Anti-Presbyopia effects
KW - Anti-oxidants
KW - Hesperetin
KW - Sclerosis of the lens
KW - α-glucosyl hesperidin
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U2 - 10.1016/j.bbrep.2020.100885
DO - 10.1016/j.bbrep.2020.100885
M3 - Article
AN - SCOPUS:85098497766
VL - 25
JO - Biochemistry and Biophysics Reports
JF - Biochemistry and Biophysics Reports
SN - 2405-5808
M1 - 100885
ER -