Orally administered manganese chloride: Enhanced detection of hepatic tumors in rats

Burkhard P. Kreft, Yuji Baba, Akihiro Tanimoto, J. Paul Finn, David D. Stark

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

To evaluate its potential as a tissue-specific hepatobiliary magnetic resonance (MR) contrast agent, manganese chloride was orally administered to rats in increasing doses of 100-1,500 μmol/kg MnCl2, and the relaxation times of liver, pancreas, kidney, and heart were measured with ex vivo relaxometry and in vivo MR imaging. Two hours after ingestion of 200 μmol/kg MnCl2, liver T1 was decreased by 48%, whereas tumor T1 decreased by only 9%. On spin-echo MR images, the signal-to-noise ratio in liver increased by 54%; the contrast-to-noise ratio in tumor, by 375%. The T1 of pancreas, kidney, and heart decreased by 8%, 23%, and 13%, respectively. At subjective assessment, the signal intensity of the upper gastrointestinal tract was reduced, likely because of the high concentration of manganese in the lumen, and delineation of the intestine from other abdominal structures was improved. These results indicate that orally administered MnCl2 causes substantial, reproducible, and tissue-specific enhancement of liver. Because enhancement of tumor was minimal, orally administered MnCl2 may potentially be used to improve detection of hepatic tumors.

Original languageEnglish
Pages (from-to)543-548
Number of pages6
JournalRadiology
Volume186
Issue number2
DOIs
Publication statusPublished - 1993 Feb

Keywords

  • Contrast media, experimental studies, 761.1229
  • Liver neoplasms, MR, 761.1214
  • Liver, MR, 761.1214
  • Magnetic resonance (MR), relaxometry
  • Manganese, 761.1229

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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