Orbital high resolution magnetic resonance imaging with fast spin echo in the acute stage of Leber's hereditary optic neuropathy

Yukihiko Mashima, Kazuhiro Oshitari, Yutaka Imamura, Suketaka Momoshima, Hayao Shiga, Yoshihisa Oguchi

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Some evidence suggests that the primary locus of the lesion in Leber's hereditary optic neuropathy (LHON) may be intraocular rather than retrobulbar. To clarify this issue, the condition of the retrobulbar portion of the optic nerve was evaluated in patients with the acute stage of LHON. High resolution MRI with fast spin echo sequences of the optic nerve complex in the orbit was carried out. Five patients with acute stage LHON were compared with seven patients with acute stage optic neuritis. On T2 weighted fast spin echo MRI, signal changes did not appear in the retrobulbar optic nerve complex in acute stage LHON. By comparison, patients with optic neuritis showed pronounced high signals in the optic nerve. Subsequent orbital MRI in the atrophic stages of the same patients with LHON showed an increase in signal intensity in the optic nerve toward the orbital apex in both eyes. The present results support the hypothesis that a primary lesion in LHON may be intraocular.

Original languageEnglish
Pages (from-to)124-127
Number of pages4
JournalJournal of Neurology Neurosurgery and Psychiatry
Volume64
Issue number1
Publication statusPublished - 1998

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Leber's Hereditary Optic Atrophy
Optic Nerve
Magnetic Resonance Imaging
Optic Neuritis
Orbit

Keywords

  • Fast spin echo sequence
  • Leber's hereditary optic neuropathy
  • MRI
  • Optic neuritis

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

Orbital high resolution magnetic resonance imaging with fast spin echo in the acute stage of Leber's hereditary optic neuropathy. / Mashima, Yukihiko; Oshitari, Kazuhiro; Imamura, Yutaka; Momoshima, Suketaka; Shiga, Hayao; Oguchi, Yoshihisa.

In: Journal of Neurology Neurosurgery and Psychiatry, Vol. 64, No. 1, 1998, p. 124-127.

Research output: Contribution to journalArticle

Mashima, Yukihiko ; Oshitari, Kazuhiro ; Imamura, Yutaka ; Momoshima, Suketaka ; Shiga, Hayao ; Oguchi, Yoshihisa. / Orbital high resolution magnetic resonance imaging with fast spin echo in the acute stage of Leber's hereditary optic neuropathy. In: Journal of Neurology Neurosurgery and Psychiatry. 1998 ; Vol. 64, No. 1. pp. 124-127.
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