Abstract
Some evidence suggests that the primary locus of the lesion in Leber's hereditary optic neuropathy (LHON) may be intraocular rather than retrobulbar. To clarify this issue, the condition of the retrobulbar portion of the optic nerve was evaluated in patients with the acute stage of LHON. High resolution MRI with fast spin echo sequences of the optic nerve complex in the orbit was carried out. Five patients with acute stage LHON were compared with seven patients with acute stage optic neuritis. On T2 weighted fast spin echo MRI, signal changes did not appear in the retrobulbar optic nerve complex in acute stage LHON. By comparison, patients with optic neuritis showed pronounced high signals in the optic nerve. Subsequent orbital MRI in the atrophic stages of the same patients with LHON showed an increase in signal intensity in the optic nerve toward the orbital apex in both eyes. The present results support the hypothesis that a primary lesion in LHON may be intraocular.
| Original language | English |
|---|---|
| Pages (from-to) | 124-127 |
| Number of pages | 4 |
| Journal | Journal of Neurology Neurosurgery and Psychiatry |
| Volume | 64 |
| Issue number | 1 |
| Publication status | Published - 1998 |
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Keywords
- Fast spin echo sequence
- Leber's hereditary optic neuropathy
- MRI
- Optic neuritis
ASJC Scopus subject areas
- Neuropsychology and Physiological Psychology
- Neuroscience(all)
- Psychiatry and Mental health
Cite this
Orbital high resolution magnetic resonance imaging with fast spin echo in the acute stage of Leber's hereditary optic neuropathy. / Mashima, Yukihiko; Oshitari, Kazuhiro; Imamura, Yutaka; Momoshima, Suketaka; Shiga, Hayao; Oguchi, Yoshihisa.
In: Journal of Neurology Neurosurgery and Psychiatry, Vol. 64, No. 1, 1998, p. 124-127.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Orbital high resolution magnetic resonance imaging with fast spin echo in the acute stage of Leber's hereditary optic neuropathy
AU - Mashima, Yukihiko
AU - Oshitari, Kazuhiro
AU - Imamura, Yutaka
AU - Momoshima, Suketaka
AU - Shiga, Hayao
AU - Oguchi, Yoshihisa
PY - 1998
Y1 - 1998
N2 - Some evidence suggests that the primary locus of the lesion in Leber's hereditary optic neuropathy (LHON) may be intraocular rather than retrobulbar. To clarify this issue, the condition of the retrobulbar portion of the optic nerve was evaluated in patients with the acute stage of LHON. High resolution MRI with fast spin echo sequences of the optic nerve complex in the orbit was carried out. Five patients with acute stage LHON were compared with seven patients with acute stage optic neuritis. On T2 weighted fast spin echo MRI, signal changes did not appear in the retrobulbar optic nerve complex in acute stage LHON. By comparison, patients with optic neuritis showed pronounced high signals in the optic nerve. Subsequent orbital MRI in the atrophic stages of the same patients with LHON showed an increase in signal intensity in the optic nerve toward the orbital apex in both eyes. The present results support the hypothesis that a primary lesion in LHON may be intraocular.
AB - Some evidence suggests that the primary locus of the lesion in Leber's hereditary optic neuropathy (LHON) may be intraocular rather than retrobulbar. To clarify this issue, the condition of the retrobulbar portion of the optic nerve was evaluated in patients with the acute stage of LHON. High resolution MRI with fast spin echo sequences of the optic nerve complex in the orbit was carried out. Five patients with acute stage LHON were compared with seven patients with acute stage optic neuritis. On T2 weighted fast spin echo MRI, signal changes did not appear in the retrobulbar optic nerve complex in acute stage LHON. By comparison, patients with optic neuritis showed pronounced high signals in the optic nerve. Subsequent orbital MRI in the atrophic stages of the same patients with LHON showed an increase in signal intensity in the optic nerve toward the orbital apex in both eyes. The present results support the hypothesis that a primary lesion in LHON may be intraocular.
KW - Fast spin echo sequence
KW - Leber's hereditary optic neuropathy
KW - MRI
KW - Optic neuritis
UR - http://www.scopus.com/inward/record.url?scp=0031960873&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031960873&partnerID=8YFLogxK
M3 - Article
C2 - 9436742
AN - SCOPUS:0031960873
VL - 64
SP - 124
EP - 127
JO - Journal of Neurology, Neurosurgery and Psychiatry
JF - Journal of Neurology, Neurosurgery and Psychiatry
SN - 0022-3050
IS - 1
ER -