Organization and Evolution of Brain Lipidome Revealed by Large-Scale Analysis of Human, Chimpanzee, Macaque, and Mouse Tissues

Katarzyna Bozek, Yuning Wei, Zheng Yan, Xiling Liu, Jieyi Xiong, Masahiro Sugimoto, Masaru Tomita, Svante Pääbo, Chet C. Sherwood, Patrick R. Hof, John J. Ely, Yan Li, Dirk Steinhauser, Lothar Willmitzer, Patrick Giavalisco, Philipp Khaitovich

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Lipids are prominent components of the nervous system. Here we performed a large-scale mass spectrometry-based analysis of the lipid composition of three brain regions as well as kidney and skeletal muscle of humans, chimpanzees, rhesus macaques, and mice. The human brain shows the most distinct lipid composition: 76% of 5,713 lipid compounds examined in our study are either enriched or depleted in the human brain. Concentration levels of lipids enriched in the brain evolve approximately four times faster among primates compared with lipids characteristic of non-neural tissues and show further acceleration of change in human neocortical regions but not in the cerebellum. Human-specific concentration changes are supported by human-specific expression changes for corresponding enzymes. These results provide the first insights into the role of lipids in human brain evolution.

Original languageEnglish
Pages (from-to)695-702
Number of pages8
JournalNeuron
Volume85
Issue number4
DOIs
Publication statusPublished - 2015 Feb 18

Fingerprint

Pan troglodytes
Macaca
Lipids
Brain
Macaca mulatta
Cerebellum
Primates
Nervous System
Mass Spectrometry
Skeletal Muscle
Kidney
Enzymes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Organization and Evolution of Brain Lipidome Revealed by Large-Scale Analysis of Human, Chimpanzee, Macaque, and Mouse Tissues. / Bozek, Katarzyna; Wei, Yuning; Yan, Zheng; Liu, Xiling; Xiong, Jieyi; Sugimoto, Masahiro; Tomita, Masaru; Pääbo, Svante; Sherwood, Chet C.; Hof, Patrick R.; Ely, John J.; Li, Yan; Steinhauser, Dirk; Willmitzer, Lothar; Giavalisco, Patrick; Khaitovich, Philipp.

In: Neuron, Vol. 85, No. 4, 18.02.2015, p. 695-702.

Research output: Contribution to journalArticle

Bozek, K, Wei, Y, Yan, Z, Liu, X, Xiong, J, Sugimoto, M, Tomita, M, Pääbo, S, Sherwood, CC, Hof, PR, Ely, JJ, Li, Y, Steinhauser, D, Willmitzer, L, Giavalisco, P & Khaitovich, P 2015, 'Organization and Evolution of Brain Lipidome Revealed by Large-Scale Analysis of Human, Chimpanzee, Macaque, and Mouse Tissues', Neuron, vol. 85, no. 4, pp. 695-702. https://doi.org/10.1016/j.neuron.2015.01.003
Bozek, Katarzyna ; Wei, Yuning ; Yan, Zheng ; Liu, Xiling ; Xiong, Jieyi ; Sugimoto, Masahiro ; Tomita, Masaru ; Pääbo, Svante ; Sherwood, Chet C. ; Hof, Patrick R. ; Ely, John J. ; Li, Yan ; Steinhauser, Dirk ; Willmitzer, Lothar ; Giavalisco, Patrick ; Khaitovich, Philipp. / Organization and Evolution of Brain Lipidome Revealed by Large-Scale Analysis of Human, Chimpanzee, Macaque, and Mouse Tissues. In: Neuron. 2015 ; Vol. 85, No. 4. pp. 695-702.
@article{f4bfdcf76cca4f3e8b76af3a5e7056b1,
title = "Organization and Evolution of Brain Lipidome Revealed by Large-Scale Analysis of Human, Chimpanzee, Macaque, and Mouse Tissues",
abstract = "Lipids are prominent components of the nervous system. Here we performed a large-scale mass spectrometry-based analysis of the lipid composition of three brain regions as well as kidney and skeletal muscle of humans, chimpanzees, rhesus macaques, and mice. The human brain shows the most distinct lipid composition: 76{\%} of 5,713 lipid compounds examined in our study are either enriched or depleted in the human brain. Concentration levels of lipids enriched in the brain evolve approximately four times faster among primates compared with lipids characteristic of non-neural tissues and show further acceleration of change in human neocortical regions but not in the cerebellum. Human-specific concentration changes are supported by human-specific expression changes for corresponding enzymes. These results provide the first insights into the role of lipids in human brain evolution.",
author = "Katarzyna Bozek and Yuning Wei and Zheng Yan and Xiling Liu and Jieyi Xiong and Masahiro Sugimoto and Masaru Tomita and Svante P{\"a}{\"a}bo and Sherwood, {Chet C.} and Hof, {Patrick R.} and Ely, {John J.} and Yan Li and Dirk Steinhauser and Lothar Willmitzer and Patrick Giavalisco and Philipp Khaitovich",
year = "2015",
month = "2",
day = "18",
doi = "10.1016/j.neuron.2015.01.003",
language = "English",
volume = "85",
pages = "695--702",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "4",

}

TY - JOUR

T1 - Organization and Evolution of Brain Lipidome Revealed by Large-Scale Analysis of Human, Chimpanzee, Macaque, and Mouse Tissues

AU - Bozek, Katarzyna

AU - Wei, Yuning

AU - Yan, Zheng

AU - Liu, Xiling

AU - Xiong, Jieyi

AU - Sugimoto, Masahiro

AU - Tomita, Masaru

AU - Pääbo, Svante

AU - Sherwood, Chet C.

AU - Hof, Patrick R.

AU - Ely, John J.

AU - Li, Yan

AU - Steinhauser, Dirk

AU - Willmitzer, Lothar

AU - Giavalisco, Patrick

AU - Khaitovich, Philipp

PY - 2015/2/18

Y1 - 2015/2/18

N2 - Lipids are prominent components of the nervous system. Here we performed a large-scale mass spectrometry-based analysis of the lipid composition of three brain regions as well as kidney and skeletal muscle of humans, chimpanzees, rhesus macaques, and mice. The human brain shows the most distinct lipid composition: 76% of 5,713 lipid compounds examined in our study are either enriched or depleted in the human brain. Concentration levels of lipids enriched in the brain evolve approximately four times faster among primates compared with lipids characteristic of non-neural tissues and show further acceleration of change in human neocortical regions but not in the cerebellum. Human-specific concentration changes are supported by human-specific expression changes for corresponding enzymes. These results provide the first insights into the role of lipids in human brain evolution.

AB - Lipids are prominent components of the nervous system. Here we performed a large-scale mass spectrometry-based analysis of the lipid composition of three brain regions as well as kidney and skeletal muscle of humans, chimpanzees, rhesus macaques, and mice. The human brain shows the most distinct lipid composition: 76% of 5,713 lipid compounds examined in our study are either enriched or depleted in the human brain. Concentration levels of lipids enriched in the brain evolve approximately four times faster among primates compared with lipids characteristic of non-neural tissues and show further acceleration of change in human neocortical regions but not in the cerebellum. Human-specific concentration changes are supported by human-specific expression changes for corresponding enzymes. These results provide the first insights into the role of lipids in human brain evolution.

UR - http://www.scopus.com/inward/record.url?scp=84925636699&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925636699&partnerID=8YFLogxK

U2 - 10.1016/j.neuron.2015.01.003

DO - 10.1016/j.neuron.2015.01.003

M3 - Article

VL - 85

SP - 695

EP - 702

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 4

ER -