Orthotopic reconstitution of human small-cell lung carcinoma after intravenous transplantation in SCID mice

T. H. Kuo, T. Kubota, M. Watanabe, T. Furukawa, S. Kase, H. Tanino, H. Nishibori, Y. Saikawa, T. Teramoto, K. Ihsibiki, M. Kitajima, R. M. Hoffman

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Abstract

We have constructed an orthotopically reconstituted model of human small-cell lung carcinoma (SCLC) by intravenous transplantation in severe combined immunodeficient (SCID) mice. Two human SCLC xenografts, H-69 and Lu-130, were disaggregated and injected through the tail vein of SCID mice. Human SCLCs were orthotopically reconstituted with multi-focal lung tumor growth in all SCID mice after intravenous injection of 5 X 106 tumor cells per mouse. The heart and liver were also seeded with actively growing SCLC. This orthotopic reconstitution model of human SCLC in SCID mice should be useful for further studies on the biological behavior and treatment of human SCLC.

Original languageEnglish
Pages (from-to)1407-1410
Number of pages4
JournalAnticancer research
Volume12
Issue number5
Publication statusPublished - 1992 Jan 1

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Keywords

  • Orthotopic reconstitution
  • SCID mouse
  • Small-cell lung carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Kuo, T. H., Kubota, T., Watanabe, M., Furukawa, T., Kase, S., Tanino, H., Nishibori, H., Saikawa, Y., Teramoto, T., Ihsibiki, K., Kitajima, M., & Hoffman, R. M. (1992). Orthotopic reconstitution of human small-cell lung carcinoma after intravenous transplantation in SCID mice. Anticancer research, 12(5), 1407-1410.