Osteoporosis associated with rheumatoid arthritis

Hideto Kameda, Tsutomu Takeuchi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Patients with rheumatoid arthritis(RA) develop both generalized and periarticular osteoporosis. Both of them are believed to be associated with increased production of inflammatory cytokines(TNF alpha, IL-1 beta, IL-6) and increased formation and activation of osteoclasts. Whether glucocorticoids work positively or negatively on generalized/periarticular osteoporosis is still controversial. RANKL has been shown to be expressed on T cells and fibroblast-like cells in the synovium, thus 'RANKL-RANK' pathway is likely to play an important role in periarticular osteoporosis and bone erosion as well as generalized osteoporosis. Among various therapies for generalized/periarticular osteoporosis in RA, anti-cytokine antibodies/antagonists and osteoclast inhibitors including bisphosphonates are promising.

Original languageEnglish
Pages (from-to)292-298
Number of pages7
JournalNippon rinsho. Japanese journal of clinical medicine
Volume61
Issue number2
Publication statusPublished - 2003
Externally publishedYes

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Osteoporosis
Rheumatoid Arthritis
Osteoclasts
Cytokines
Synovial Membrane
Diphosphonates
Interleukin-1beta
Glucocorticoids
Anti-Idiotypic Antibodies
Interleukin-6
Tumor Necrosis Factor-alpha
Fibroblasts
T-Lymphocytes
Bone and Bones
Therapeutics

Cite this

Osteoporosis associated with rheumatoid arthritis. / Kameda, Hideto; Takeuchi, Tsutomu.

In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 61, No. 2, 2003, p. 292-298.

Research output: Contribution to journalArticle

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