Abstract
Background:Preprocedural dual antiplatelet therapy (DAPT) in percutaneous coronary interventions (PCI) has been shown to improve outcomes; however, the efficacy of the procedure and its complications in Japanese patients remain largely unexplored, so we examined the risks and benefits of DAPT before PCI and its association with in-hospital outcomes.Methods and Results:We analyzed data from patients who had undergone PCI at 12 centers within the metropolitan Tokyo area between September 2008 and September 2013.Our study group comprised 6,528 patients, of whom 2,079 (31.8%) were not administered preprocedural DAPT. Non-use of preprocedural DAPT was associated with death, postprocedural shock, or heart failure (odds ratio [OR]: 1.47, 95% confidence interval [CI]: 1.10–1.96, P=0.009), and postprocedural myocardial infarction (OR: 1.41, 95% CI: 1.18–1.69, P
| Original language | English |
|---|---|
| Pages (from-to) | 2598-2607 |
| Number of pages | 10 |
| Journal | Circulation Journal |
| Volume | 79 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2015 Nov 25 |
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Keywords
- Bleeding
- Dual antiplatelet therapy
- Japanese
- Percutaneous coronary intervention
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Outcomes of percutaneous coronary intervention performed with or without preprocedural dual antiplatelet therapy. / Ikegami, Yukinori; Kosaka, Shun; Miyata, Hiroaki; Ueda, Ikuko; Fuse, Jun; Sakamoto, Munehisa; Shiraishi, Yasuyuki; Numasawa, Yohei; Negishi, Koji; Nakamura, Iwao; Maekawa, Yuichiro; Momiyama, Yukihiko; Fukuda, Keiichi.
In: Circulation Journal, Vol. 79, No. 12, 25.11.2015, p. 2598-2607.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Outcomes of percutaneous coronary intervention performed with or without preprocedural dual antiplatelet therapy
AU - Ikegami, Yukinori
AU - Kosaka, Shun
AU - Miyata, Hiroaki
AU - Ueda, Ikuko
AU - Fuse, Jun
AU - Sakamoto, Munehisa
AU - Shiraishi, Yasuyuki
AU - Numasawa, Yohei
AU - Negishi, Koji
AU - Nakamura, Iwao
AU - Maekawa, Yuichiro
AU - Momiyama, Yukihiko
AU - Fukuda, Keiichi
PY - 2015/11/25
Y1 - 2015/11/25
N2 - Background:Preprocedural dual antiplatelet therapy (DAPT) in percutaneous coronary interventions (PCI) has been shown to improve outcomes; however, the efficacy of the procedure and its complications in Japanese patients remain largely unexplored, so we examined the risks and benefits of DAPT before PCI and its association with in-hospital outcomes.Methods and Results:We analyzed data from patients who had undergone PCI at 12 centers within the metropolitan Tokyo area between September 2008 and September 2013.Our study group comprised 6,528 patients, of whom 2,079 (31.8%) were not administered preprocedural DAPT. Non-use of preprocedural DAPT was associated with death, postprocedural shock, or heart failure (odds ratio [OR]: 1.47, 95% confidence interval [CI]: 1.10–1.96, P=0.009), and postprocedural myocardial infarction (OR: 1.41, 95% CI: 1.18–1.69, P
AB - Background:Preprocedural dual antiplatelet therapy (DAPT) in percutaneous coronary interventions (PCI) has been shown to improve outcomes; however, the efficacy of the procedure and its complications in Japanese patients remain largely unexplored, so we examined the risks and benefits of DAPT before PCI and its association with in-hospital outcomes.Methods and Results:We analyzed data from patients who had undergone PCI at 12 centers within the metropolitan Tokyo area between September 2008 and September 2013.Our study group comprised 6,528 patients, of whom 2,079 (31.8%) were not administered preprocedural DAPT. Non-use of preprocedural DAPT was associated with death, postprocedural shock, or heart failure (odds ratio [OR]: 1.47, 95% confidence interval [CI]: 1.10–1.96, P=0.009), and postprocedural myocardial infarction (OR: 1.41, 95% CI: 1.18–1.69, P
KW - Bleeding
KW - Dual antiplatelet therapy
KW - Japanese
KW - Percutaneous coronary intervention
UR - http://www.scopus.com/inward/record.url?scp=84961651959&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84961651959&partnerID=8YFLogxK
U2 - 10.1253/circj.CJ-15-0484
DO - 10.1253/circj.CJ-15-0484
M3 - Article
VL - 79
SP - 2598
EP - 2607
JO - Circulation Journal
JF - Circulation Journal
SN - 1346-9843
IS - 12
ER -