Outcomes of segmentectomy and wedge resection for pulmonary metastases from colorectal cancer

Satoshi Shiono, Takehiro Okumura, Narikazu Boku, Tomoyuki Hishida, Yasuhisa Ohde, Yukinori Sakao, Katsuo Yoshiya, Ichinosuke Hyodo, Keita Mori, Haruhiko Kondo

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

OBJECTIVES: Although wedge resection is the most common surgical procedure for pulmonary metastases from colorectal cancer, there are few reports about segmentectomy for colorectal metastasectomy. METHODS: This was a subset analysis of a Japanese nationwide retrospective study of resected pulmonary metastases from colorectal cancer. The study included 553 patients who underwent segmentectomies (n = 98) or wedge resections (n = 455) without preoperative chemotherapy between January 2004 and December 2008. Recurrence patterns, recurrence-free survival and overall survival were analysed for each procedure. RESULTS: As for the patients' background factors, only the median size of resected metastases was different between patients with segmentectomies (median 18 mm, range 5-50 mm) and wedge resections (14 mm, 5-51 mm) (P < 0.001). Prolonged air leak developed more frequently in those undergoing segmentectomy compared with wedge resection (5.1% vs 1.8%) (P = 0.048). The resection-margin recurrence rate was higher in patients who underwent wedge resection compared with segmentectomy (7.3% vs 2.0%; P = 0.035). The 5-year recurrence-free survival was 48.8% in patients with segmentectomy and 36.0% in patients with wedge resections. The 5-year overall survival was 80.1% in patients with segmentectomy and 68.5% in patients with wedge resection. Multivariable analysis revealed that the surgical procedure, segmentectomy, was a significant favourable factor for recurrence (hazard ratio: 0.63, 95% confidence interval: 0.44-0.87, P = 0.005), but not for overall survival (hazard ratio: 0.65, 95% confidence interval: 0.38-1.05, P = 0.080). CONCLUSIONS: Segmentectomy demonstrated a good efficacy with less resection-margin recurrence in patients with resectable pulmonary-limited metastasis from colorectal cancer.

Original languageEnglish
Pages (from-to)504-510
Number of pages7
JournalEuropean Journal of Cardio-thoracic Surgery
Volume51
Issue number3
DOIs
Publication statusPublished - 2017 Mar 1
Externally publishedYes

Fingerprint

Segmental Mastectomy
Colorectal Neoplasms
Neoplasm Metastasis
Lung
Recurrence
Survival
Pulmonary Surgical Procedures
Metastasectomy
Confidence Intervals
Retrospective Studies
Air
Drug Therapy

Keywords

  • Metastasectomy
  • Segmentectomy
  • Wedge resection

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Outcomes of segmentectomy and wedge resection for pulmonary metastases from colorectal cancer. / Shiono, Satoshi; Okumura, Takehiro; Boku, Narikazu; Hishida, Tomoyuki; Ohde, Yasuhisa; Sakao, Yukinori; Yoshiya, Katsuo; Hyodo, Ichinosuke; Mori, Keita; Kondo, Haruhiko.

In: European Journal of Cardio-thoracic Surgery, Vol. 51, No. 3, 01.03.2017, p. 504-510.

Research output: Contribution to journalArticle

Shiono, S, Okumura, T, Boku, N, Hishida, T, Ohde, Y, Sakao, Y, Yoshiya, K, Hyodo, I, Mori, K & Kondo, H 2017, 'Outcomes of segmentectomy and wedge resection for pulmonary metastases from colorectal cancer', European Journal of Cardio-thoracic Surgery, vol. 51, no. 3, pp. 504-510. https://doi.org/10.1093/ejcts/ezw322
Shiono, Satoshi ; Okumura, Takehiro ; Boku, Narikazu ; Hishida, Tomoyuki ; Ohde, Yasuhisa ; Sakao, Yukinori ; Yoshiya, Katsuo ; Hyodo, Ichinosuke ; Mori, Keita ; Kondo, Haruhiko. / Outcomes of segmentectomy and wedge resection for pulmonary metastases from colorectal cancer. In: European Journal of Cardio-thoracic Surgery. 2017 ; Vol. 51, No. 3. pp. 504-510.
@article{8a5ff7d63de74128a58bbc53645038f7,
title = "Outcomes of segmentectomy and wedge resection for pulmonary metastases from colorectal cancer",
abstract = "OBJECTIVES: Although wedge resection is the most common surgical procedure for pulmonary metastases from colorectal cancer, there are few reports about segmentectomy for colorectal metastasectomy. METHODS: This was a subset analysis of a Japanese nationwide retrospective study of resected pulmonary metastases from colorectal cancer. The study included 553 patients who underwent segmentectomies (n = 98) or wedge resections (n = 455) without preoperative chemotherapy between January 2004 and December 2008. Recurrence patterns, recurrence-free survival and overall survival were analysed for each procedure. RESULTS: As for the patients' background factors, only the median size of resected metastases was different between patients with segmentectomies (median 18 mm, range 5-50 mm) and wedge resections (14 mm, 5-51 mm) (P < 0.001). Prolonged air leak developed more frequently in those undergoing segmentectomy compared with wedge resection (5.1{\%} vs 1.8{\%}) (P = 0.048). The resection-margin recurrence rate was higher in patients who underwent wedge resection compared with segmentectomy (7.3{\%} vs 2.0{\%}; P = 0.035). The 5-year recurrence-free survival was 48.8{\%} in patients with segmentectomy and 36.0{\%} in patients with wedge resections. The 5-year overall survival was 80.1{\%} in patients with segmentectomy and 68.5{\%} in patients with wedge resection. Multivariable analysis revealed that the surgical procedure, segmentectomy, was a significant favourable factor for recurrence (hazard ratio: 0.63, 95{\%} confidence interval: 0.44-0.87, P = 0.005), but not for overall survival (hazard ratio: 0.65, 95{\%} confidence interval: 0.38-1.05, P = 0.080). CONCLUSIONS: Segmentectomy demonstrated a good efficacy with less resection-margin recurrence in patients with resectable pulmonary-limited metastasis from colorectal cancer.",
keywords = "Metastasectomy, Segmentectomy, Wedge resection",
author = "Satoshi Shiono and Takehiro Okumura and Narikazu Boku and Tomoyuki Hishida and Yasuhisa Ohde and Yukinori Sakao and Katsuo Yoshiya and Ichinosuke Hyodo and Keita Mori and Haruhiko Kondo",
year = "2017",
month = "3",
day = "1",
doi = "10.1093/ejcts/ezw322",
language = "English",
volume = "51",
pages = "504--510",
journal = "European Journal of Cardio-thoracic Surgery",
issn = "1010-7940",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Outcomes of segmentectomy and wedge resection for pulmonary metastases from colorectal cancer

AU - Shiono, Satoshi

AU - Okumura, Takehiro

AU - Boku, Narikazu

AU - Hishida, Tomoyuki

AU - Ohde, Yasuhisa

AU - Sakao, Yukinori

AU - Yoshiya, Katsuo

AU - Hyodo, Ichinosuke

AU - Mori, Keita

AU - Kondo, Haruhiko

PY - 2017/3/1

Y1 - 2017/3/1

N2 - OBJECTIVES: Although wedge resection is the most common surgical procedure for pulmonary metastases from colorectal cancer, there are few reports about segmentectomy for colorectal metastasectomy. METHODS: This was a subset analysis of a Japanese nationwide retrospective study of resected pulmonary metastases from colorectal cancer. The study included 553 patients who underwent segmentectomies (n = 98) or wedge resections (n = 455) without preoperative chemotherapy between January 2004 and December 2008. Recurrence patterns, recurrence-free survival and overall survival were analysed for each procedure. RESULTS: As for the patients' background factors, only the median size of resected metastases was different between patients with segmentectomies (median 18 mm, range 5-50 mm) and wedge resections (14 mm, 5-51 mm) (P < 0.001). Prolonged air leak developed more frequently in those undergoing segmentectomy compared with wedge resection (5.1% vs 1.8%) (P = 0.048). The resection-margin recurrence rate was higher in patients who underwent wedge resection compared with segmentectomy (7.3% vs 2.0%; P = 0.035). The 5-year recurrence-free survival was 48.8% in patients with segmentectomy and 36.0% in patients with wedge resections. The 5-year overall survival was 80.1% in patients with segmentectomy and 68.5% in patients with wedge resection. Multivariable analysis revealed that the surgical procedure, segmentectomy, was a significant favourable factor for recurrence (hazard ratio: 0.63, 95% confidence interval: 0.44-0.87, P = 0.005), but not for overall survival (hazard ratio: 0.65, 95% confidence interval: 0.38-1.05, P = 0.080). CONCLUSIONS: Segmentectomy demonstrated a good efficacy with less resection-margin recurrence in patients with resectable pulmonary-limited metastasis from colorectal cancer.

AB - OBJECTIVES: Although wedge resection is the most common surgical procedure for pulmonary metastases from colorectal cancer, there are few reports about segmentectomy for colorectal metastasectomy. METHODS: This was a subset analysis of a Japanese nationwide retrospective study of resected pulmonary metastases from colorectal cancer. The study included 553 patients who underwent segmentectomies (n = 98) or wedge resections (n = 455) without preoperative chemotherapy between January 2004 and December 2008. Recurrence patterns, recurrence-free survival and overall survival were analysed for each procedure. RESULTS: As for the patients' background factors, only the median size of resected metastases was different between patients with segmentectomies (median 18 mm, range 5-50 mm) and wedge resections (14 mm, 5-51 mm) (P < 0.001). Prolonged air leak developed more frequently in those undergoing segmentectomy compared with wedge resection (5.1% vs 1.8%) (P = 0.048). The resection-margin recurrence rate was higher in patients who underwent wedge resection compared with segmentectomy (7.3% vs 2.0%; P = 0.035). The 5-year recurrence-free survival was 48.8% in patients with segmentectomy and 36.0% in patients with wedge resections. The 5-year overall survival was 80.1% in patients with segmentectomy and 68.5% in patients with wedge resection. Multivariable analysis revealed that the surgical procedure, segmentectomy, was a significant favourable factor for recurrence (hazard ratio: 0.63, 95% confidence interval: 0.44-0.87, P = 0.005), but not for overall survival (hazard ratio: 0.65, 95% confidence interval: 0.38-1.05, P = 0.080). CONCLUSIONS: Segmentectomy demonstrated a good efficacy with less resection-margin recurrence in patients with resectable pulmonary-limited metastasis from colorectal cancer.

KW - Metastasectomy

KW - Segmentectomy

KW - Wedge resection

UR - http://www.scopus.com/inward/record.url?scp=85020011841&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020011841&partnerID=8YFLogxK

U2 - 10.1093/ejcts/ezw322

DO - 10.1093/ejcts/ezw322

M3 - Article

C2 - 27773868

AN - SCOPUS:85020011841

VL - 51

SP - 504

EP - 510

JO - European Journal of Cardio-thoracic Surgery

JF - European Journal of Cardio-thoracic Surgery

SN - 1010-7940

IS - 3

ER -