Overexpression of Bcl-2 and Mutations in p53 and K-ras in Resected Human Non-Small Cell Lung Cancers

Yuko Kitagawa, Fred Wong, Patrick Lo, Mark Elliott, Lorraine M. Verburgt, James C. Hogg, Maleki Daya

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23 Citations (Scopus)

Abstract

We investigated expression of Bcl-2, mutations in p53, and K-ras oncogene in 51 resected human non-small cell lung cancers. The studies were designed to test for the possibility of cooperativity between these oncogenes and p53 in the pathogenesis of lung cancer. An inverse relationship was found between expression of Bcl-2 and mutant p53 by immunohistochemistry (P < 0.01; Fisher exact test), suggesting that either Bcl-2 overexpression or mutations in p53 may fulfill a critical function in the pathogenesis of human non-small cell lung cancers. Tumors that harbored K-ras codon 12 mutations seldom had p53 mutations or overexpressed Bcl-2. Statistical analysis of these data showed that mutations in p53 and K-ras or overexpression of Bcl-2 and mutations in K-ras occurred at a frequency that could be explained only by chance [P > 0.1 in each case (Fisher exact tests)]. This suggests that cooperativity between mutant K-ras and mutant p53 or mutant K-ras and overexpressed Bcl-2 is not a common mechanism in the pathogenesis of human non-small cell lung cancers.

Original languageEnglish
Pages (from-to)45-54
Number of pages10
JournalAmerican journal of respiratory cell and molecular biology
Volume15
Issue number1
DOIs
Publication statusPublished - 1996 Jan 1
Externally publishedYes

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ASJC Scopus subject areas

  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Clinical Biochemistry
  • Cell Biology

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