Overexpression of KIT in chromophobe renal cell carcinoma

Ken Yamazaki, Michiie Sakamoto, Tsutomu Ohta, Yae Kanai, Misao Ohki, Setsuo Hirohashi

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

We analysed gene-expression profiles in 15 surgical specimens of conventional, papillary, and chromophobe renal cell carcinomas (RCCs) using high-density oligonucleotide arrays. From about 12 000 genes targeted by the array, 67 were upregulated specifically in each histological type of RCC. The oncogene KIT was one of the genes whose expression was upregulated specifically in chromophobe RCCs. Immunohistochemical analysis demonstrated the KIT gene product on the cell membrane of chromophobe RCC in all cases, although it was not detected in conventional RCCs or non-neoplastic kidneys except for weak staining in the cytoplasm of renal tubules. These results suggest that each histological subtype of RCC has a unique gene-expression profile, and in particular indicates for the first time that KIT could be a useful marker for chromophobe RCC. As overexpression of KIT might be involved in tumor growth, KIT could be a new therapeutic target in this special type of RCC.

Original languageEnglish
Pages (from-to)847-852
Number of pages6
JournalOncogene
Volume22
Issue number6
DOIs
Publication statusPublished - 2003 Feb 13

Keywords

  • Gene-expression profiling
  • KIT
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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