Overview: Helicobacter pylori and extragastric disease

Hidekazu Suzuki, Barry James Marshall, Toshifumi Hibi

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Isolation of the gastric spiral bacterium Helicobacter pylori totally reversed the false dogma that the stomach was sterile. In addition to its causal role in peptic ulceration, the newly identified bacterium has now been implicated in other gastric and even extragastric diseases, including chronic atrophic gastritis, gastric MALT lymphoma, gastric cancer, functional dyspepsia, idiopathic thrombocytopenic purpura (ITP), iron deficiency anemia, chronic urticaria, ischemic heart disease, and others. The majority of the reports are anecdotal, epidemiologic, or eradication studies, but there are also relevant in vitro studies. ITP represents one disease showing a strong link with H pylori infection. There are also accumulating data on the role of H pylori infection in iron deficiency anemia and ischemic heart disease. In summary, the association between H pylori infection and other extragut diseases is still controversial but worthy of further investigation.

Original languageEnglish
Pages (from-to)291-300
Number of pages10
JournalInternational Journal of Hematology
Volume84
Issue number4
DOIs
Publication statusPublished - 2006 Nov

Fingerprint

Pylorus
Helicobacter pylori
Stomach
Idiopathic Thrombocytopenic Purpura
Iron-Deficiency Anemias
Myocardial Ischemia
Infection
Bacteria
Atrophic Gastritis
Marginal Zone B-Cell Lymphoma
Dyspepsia
Urticaria
Stomach Neoplasms
Digestion
Chronic Disease

Keywords

  • Cag A
  • Gastritis
  • Idiopathic thrombocytopenic purpura
  • Iron deficiency anemia
  • Peptic ulcer

ASJC Scopus subject areas

  • Hematology

Cite this

Overview : Helicobacter pylori and extragastric disease. / Suzuki, Hidekazu; Marshall, Barry James; Hibi, Toshifumi.

In: International Journal of Hematology, Vol. 84, No. 4, 11.2006, p. 291-300.

Research output: Contribution to journalArticle

Suzuki, Hidekazu ; Marshall, Barry James ; Hibi, Toshifumi. / Overview : Helicobacter pylori and extragastric disease. In: International Journal of Hematology. 2006 ; Vol. 84, No. 4. pp. 291-300.
@article{39e031c1f6bf4e97a7f504966896642f,
title = "Overview: Helicobacter pylori and extragastric disease",
abstract = "Isolation of the gastric spiral bacterium Helicobacter pylori totally reversed the false dogma that the stomach was sterile. In addition to its causal role in peptic ulceration, the newly identified bacterium has now been implicated in other gastric and even extragastric diseases, including chronic atrophic gastritis, gastric MALT lymphoma, gastric cancer, functional dyspepsia, idiopathic thrombocytopenic purpura (ITP), iron deficiency anemia, chronic urticaria, ischemic heart disease, and others. The majority of the reports are anecdotal, epidemiologic, or eradication studies, but there are also relevant in vitro studies. ITP represents one disease showing a strong link with H pylori infection. There are also accumulating data on the role of H pylori infection in iron deficiency anemia and ischemic heart disease. In summary, the association between H pylori infection and other extragut diseases is still controversial but worthy of further investigation.",
keywords = "Cag A, Gastritis, Idiopathic thrombocytopenic purpura, Iron deficiency anemia, Peptic ulcer",
author = "Hidekazu Suzuki and Marshall, {Barry James} and Toshifumi Hibi",
year = "2006",
month = "11",
doi = "10.1532/IJH97.06180",
language = "English",
volume = "84",
pages = "291--300",
journal = "International Journal of Hematology",
issn = "0925-5710",
publisher = "Springer Japan",
number = "4",

}

TY - JOUR

T1 - Overview

T2 - Helicobacter pylori and extragastric disease

AU - Suzuki, Hidekazu

AU - Marshall, Barry James

AU - Hibi, Toshifumi

PY - 2006/11

Y1 - 2006/11

N2 - Isolation of the gastric spiral bacterium Helicobacter pylori totally reversed the false dogma that the stomach was sterile. In addition to its causal role in peptic ulceration, the newly identified bacterium has now been implicated in other gastric and even extragastric diseases, including chronic atrophic gastritis, gastric MALT lymphoma, gastric cancer, functional dyspepsia, idiopathic thrombocytopenic purpura (ITP), iron deficiency anemia, chronic urticaria, ischemic heart disease, and others. The majority of the reports are anecdotal, epidemiologic, or eradication studies, but there are also relevant in vitro studies. ITP represents one disease showing a strong link with H pylori infection. There are also accumulating data on the role of H pylori infection in iron deficiency anemia and ischemic heart disease. In summary, the association between H pylori infection and other extragut diseases is still controversial but worthy of further investigation.

AB - Isolation of the gastric spiral bacterium Helicobacter pylori totally reversed the false dogma that the stomach was sterile. In addition to its causal role in peptic ulceration, the newly identified bacterium has now been implicated in other gastric and even extragastric diseases, including chronic atrophic gastritis, gastric MALT lymphoma, gastric cancer, functional dyspepsia, idiopathic thrombocytopenic purpura (ITP), iron deficiency anemia, chronic urticaria, ischemic heart disease, and others. The majority of the reports are anecdotal, epidemiologic, or eradication studies, but there are also relevant in vitro studies. ITP represents one disease showing a strong link with H pylori infection. There are also accumulating data on the role of H pylori infection in iron deficiency anemia and ischemic heart disease. In summary, the association between H pylori infection and other extragut diseases is still controversial but worthy of further investigation.

KW - Cag A

KW - Gastritis

KW - Idiopathic thrombocytopenic purpura

KW - Iron deficiency anemia

KW - Peptic ulcer

UR - http://www.scopus.com/inward/record.url?scp=33847650869&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33847650869&partnerID=8YFLogxK

U2 - 10.1532/IJH97.06180

DO - 10.1532/IJH97.06180

M3 - Article

C2 - 17118754

AN - SCOPUS:33847650869

VL - 84

SP - 291

EP - 300

JO - International Journal of Hematology

JF - International Journal of Hematology

SN - 0925-5710

IS - 4

ER -