Abstract
An aqueous solution of d-α-tocopherol solubilized with sodium deoxycholate became colored on standing, probably due to air oxidation. 5- Formyl-7,8-dimethyltocol (1) and 7-formyl-5,8-dimethyltocol (2) were isolated from the solution and concluded to be responsible for the coloration. In oxidation of aqueous solutions of d-α-tocopherol, the time course of formation of products was followed by analytical HPLC. The main oxidation product was 1 in solutions solubilized with sodium deoxycholate and sodium cholate, whereas α-tocoquinone was the main product in those solubilized with 2,6-di-O-methyl-β-cyclodextrin.
| Original language | English |
|---|---|
| Pages (from-to) | 923-927 |
| Number of pages | 5 |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 47 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 1999 Jul |
Keywords
- 5-formyl-7,8-dimethyltocol
- 7-formyl-5,8- dimethyltocol
- Sodium cholate
- Sodium deoxycholate
- d-α-tocopherol
- α-tocoquinone
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery