Oxidative Kinetic Resolution of Acyclic Amines Based on Equilibrium Control

Kodai Saito, Hiromitsu Miyashita, Yui Ito, Masahiro Yamanaka, Takahiko Akiyama

Research output: Contribution to journalArticle

Abstract

An oxidative kinetic resolution of racemic acyclic amines was developed using an imine derivative as the resolving reagent and chiral phosphoric acid as the catalyst to give enantiomers in good yields with high to excellent enantioselectivities. The key to success of the title reaction was the equilibrium control by adjusting the ratio of the resolving reagent, and unique enantiodivergence was observed depending on the equilibrium displacement.

Original languageEnglish
Pages (from-to)3128-3134
Number of pages7
JournalOrganic Letters
Volume22
Issue number8
DOIs
Publication statusPublished - 2020 Apr 17

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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