Abstract
An oxidative kinetic resolution of racemic acyclic amines was developed using an imine derivative as the resolving reagent and chiral phosphoric acid as the catalyst to give enantiomers in good yields with high to excellent enantioselectivities. The key to success of the title reaction was the equilibrium control by adjusting the ratio of the resolving reagent, and unique enantiodivergence was observed depending on the equilibrium displacement.
Original language | English |
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Pages (from-to) | 3128-3134 |
Number of pages | 7 |
Journal | Organic Letters |
Volume | 22 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2020 Apr 17 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry