Oxidative stress and inflammation: hypothesis for the mechanism of aging

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Oxidative stress due to free radicals is related to the pathogenesis of many chronic disorders including cancer, inflammation, and neurological diseases. Oxidative stress such as aging and light exposure is also considered to be associated with age-related macular degeneration and cataract. The ocular surface is chronically exposed to oxidative stress including ultraviolet light, the oxygen in air, and changes in oxygen pressure due to blinking. We demonstrated that a rat dry eye model with a jogging board showed corneal epithelial disoders and elevated levels of oxidative stress, suggesting that the pathogenesis of epithelial disorders in dry eye with low frequency of blinking is related to oxidative stress. Next, using a model of laser-induced choroidal neovascularization (CNV), we showed that angiotensin receptormediated inflammation is required for the development of CNV. We also demonstrated that mice deficient in superoxide dismutase (SOD) showed typical clinical features of AMD. Finally, we proposed our thoughts about regenerative medicine, that is, to maintain quiescent stem cells, we have to regulate the aging of stem cells.

Original languageEnglish
JournalNippon Ganka Gakkai zasshi
Volume111
Issue number3
Publication statusPublished - 2007 Mar

Fingerprint

Oxidative Stress
Inflammation
Blinking
Choroidal Neovascularization
Stem Cells
Jogging
Oxygen
Regenerative Medicine
Angiotensins
Macular Degeneration
Ultraviolet Rays
Cataract
Superoxide Dismutase
Free Radicals
Lasers
Air
Light
Pressure
Neoplasms

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Oxidative stress and inflammation : hypothesis for the mechanism of aging. / Tsubota, Kazuo.

In: Nippon Ganka Gakkai zasshi, Vol. 111, No. 3, 03.2007.

Research output: Contribution to journalArticle

@article{414059819be24cadabda9c92324e0d3a,
title = "Oxidative stress and inflammation: hypothesis for the mechanism of aging",
abstract = "Oxidative stress due to free radicals is related to the pathogenesis of many chronic disorders including cancer, inflammation, and neurological diseases. Oxidative stress such as aging and light exposure is also considered to be associated with age-related macular degeneration and cataract. The ocular surface is chronically exposed to oxidative stress including ultraviolet light, the oxygen in air, and changes in oxygen pressure due to blinking. We demonstrated that a rat dry eye model with a jogging board showed corneal epithelial disoders and elevated levels of oxidative stress, suggesting that the pathogenesis of epithelial disorders in dry eye with low frequency of blinking is related to oxidative stress. Next, using a model of laser-induced choroidal neovascularization (CNV), we showed that angiotensin receptormediated inflammation is required for the development of CNV. We also demonstrated that mice deficient in superoxide dismutase (SOD) showed typical clinical features of AMD. Finally, we proposed our thoughts about regenerative medicine, that is, to maintain quiescent stem cells, we have to regulate the aging of stem cells.",
author = "Kazuo Tsubota",
year = "2007",
month = "3",
language = "English",
volume = "111",
journal = "Nippon Ganka Gakkai zasshi",
issn = "0029-0203",
publisher = "Nippon Ganka Gakkai",
number = "3",

}

TY - JOUR

T1 - Oxidative stress and inflammation

T2 - hypothesis for the mechanism of aging

AU - Tsubota, Kazuo

PY - 2007/3

Y1 - 2007/3

N2 - Oxidative stress due to free radicals is related to the pathogenesis of many chronic disorders including cancer, inflammation, and neurological diseases. Oxidative stress such as aging and light exposure is also considered to be associated with age-related macular degeneration and cataract. The ocular surface is chronically exposed to oxidative stress including ultraviolet light, the oxygen in air, and changes in oxygen pressure due to blinking. We demonstrated that a rat dry eye model with a jogging board showed corneal epithelial disoders and elevated levels of oxidative stress, suggesting that the pathogenesis of epithelial disorders in dry eye with low frequency of blinking is related to oxidative stress. Next, using a model of laser-induced choroidal neovascularization (CNV), we showed that angiotensin receptormediated inflammation is required for the development of CNV. We also demonstrated that mice deficient in superoxide dismutase (SOD) showed typical clinical features of AMD. Finally, we proposed our thoughts about regenerative medicine, that is, to maintain quiescent stem cells, we have to regulate the aging of stem cells.

AB - Oxidative stress due to free radicals is related to the pathogenesis of many chronic disorders including cancer, inflammation, and neurological diseases. Oxidative stress such as aging and light exposure is also considered to be associated with age-related macular degeneration and cataract. The ocular surface is chronically exposed to oxidative stress including ultraviolet light, the oxygen in air, and changes in oxygen pressure due to blinking. We demonstrated that a rat dry eye model with a jogging board showed corneal epithelial disoders and elevated levels of oxidative stress, suggesting that the pathogenesis of epithelial disorders in dry eye with low frequency of blinking is related to oxidative stress. Next, using a model of laser-induced choroidal neovascularization (CNV), we showed that angiotensin receptormediated inflammation is required for the development of CNV. We also demonstrated that mice deficient in superoxide dismutase (SOD) showed typical clinical features of AMD. Finally, we proposed our thoughts about regenerative medicine, that is, to maintain quiescent stem cells, we have to regulate the aging of stem cells.

UR - http://www.scopus.com/inward/record.url?scp=34250192248&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34250192248&partnerID=8YFLogxK

M3 - Article

C2 - 17402562

AN - SCOPUS:34250192248

VL - 111

JO - Nippon Ganka Gakkai zasshi

JF - Nippon Ganka Gakkai zasshi

SN - 0029-0203

IS - 3

ER -