Oxidative stress in pathogenesis of COPD

Tomoko Betsuyaku

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cigarette smoke and aging are major risk factors of chronic obstructive pulmonary disease(COPD). It remains unsolved how long -term smoking with age affects the molecular responses in the lung. Respiratory tract is the major interface to the environment and is rich in glutathione, which protects lung from oxidative stress. We performed bronchoalveolar lavage for nonsmokers and smokers of various ages, who were further categorized according to the presence of emphysema on high-resolution computed tomography. We thus evaluated glutathione antioxidant system in BAL fluid. Characterization of older smokers with long-term smoking histories, contrasted with young recent smokers, may in part explain the predisposition of the lungs to destructive lung diseases. On the other hands, oxidative stress results from an imbalance in aerobic metabolism and poses a serious threat to cellular apoptosis, leading to emphysematous lung destruction. The therapeutic interference with targeted up-regulation of protective mechanisms might be critical for the success of future COPD therapies.

Original languageEnglish
Pages (from-to)633-636
Number of pages4
JournalNippon rinsho. Japanese journal of clinical medicine
Volume65
Issue number4
Publication statusPublished - 2007 Apr
Externally publishedYes

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Chronic Obstructive Pulmonary Disease
Oxidative Stress
Lung
Glutathione
Smoking
Dimercaprol
Emphysema
Bronchoalveolar Lavage
Smoke
Tobacco Products
Respiratory System
Lung Diseases
Up-Regulation
Antioxidants
Tomography
Apoptosis
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Oxidative stress in pathogenesis of COPD. / Betsuyaku, Tomoko.

In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 65, No. 4, 04.2007, p. 633-636.

Research output: Contribution to journalArticle

Betsuyaku, Tomoko. / Oxidative stress in pathogenesis of COPD. In: Nippon rinsho. Japanese journal of clinical medicine. 2007 ; Vol. 65, No. 4. pp. 633-636.
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