Oxidative stress in the RPE and its contribution to AMD pathogenesis: Implication of light exposure

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

The retinal pigment epithelium (RPE) is a single layer of cuboidal cells that develops from the neural tube as well as neural retina does, and is therefore considered part of the central nervous system. While the neural retina receives light and converts it to electrical signals to process information and transfer it to the brain, the RPE acts as an essential coordinator of the retinal microenvironment for appropriate retinal neural function. Reactive oxygen species (ROS) are generated during basal cellular metabolic processes. Moreover, daily exposure to light stimuli enhances the production of ROS in the RPE and the neural retina, the excessive accumulation of which contributes to retinal pathogenesis. In this section, oxidative stress in the RPE and its proposed contribution to age-related macular degeneration (AMD) are discussed, reviewing recent in vivo and in vitro studies that support the role of oxidative stress in the development and progression of AMD.

Original languageEnglish
Title of host publicationNeuroprotection and Neuroregeneration for Retinal Diseases
PublisherSpringer Japan
Pages239-253
Number of pages15
ISBN (Electronic)9784431549659
ISBN (Print)4431549641, 9784431549642
DOIs
Publication statusPublished - 2014 May 1

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Keywords

  • Inflammation
  • Light exposure
  • Reactive oxygen species (ROS)
  • Retinal pigment epithelium (RPE)
  • Tight junction

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ozawa, Y. (2014). Oxidative stress in the RPE and its contribution to AMD pathogenesis: Implication of light exposure. In Neuroprotection and Neuroregeneration for Retinal Diseases (pp. 239-253). Springer Japan. https://doi.org/10.1007/978-4-431-54965-9_17