Oxygenation of hypoxic region in solid tumor by administration of human serum albumin incorporating synthetic hemes

Koichi Kobayashi; Teruyuki Komatsu; Arifumi Iwamaru; Yasuko Matsukawa; Hirohisa Horinouchi; Masazumi Watanabe; Eishun Tsuchida

doi:10.1002/jbm.a.10323

Oxygenation of hypoxic region in solid tumor by administration of human serum albumin incorporating synthetic hemes

Koichi Kobayashi, Teruyuki Komatsu, Arifumi Iwamaru, Yasuko Matsukawa, Hirohisa Horinouchi, Masazumi Watanabe, Eishun Tsuchida

School of Medicine

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Recombinant human serum albumin incorporating synthetic heme (rHSA-FeP) was tested for its ability to increase O₂ tension in the hypoxia of the solid tumor rat model. By the direct administration of the rHSA-FeP solution (10 mL/kg) via the aorta descendens to the ascites hepatoma LY80 tumor on the right femur, the O₂ tension of the hypoxic region immediately increased to 3.45 ± 1.43 Torr, which corresponds to a 2.4-fold increase compared to that of the baseline value. These high O₂ levels continued for 300 s after the infusion. The rHSA-FeP solution can be utilized not only as a red blood cell substitute but also as an O₂-carrying medicine for the effective reoxygenation of the hypoxia solid tumor.

Original language	English
Pages (from-to)	48-51
Number of pages	4
Journal	Journal of Biomedical Materials Research - Part A
Volume	64
Issue number	1
DOIs	https://doi.org/10.1002/jbm.a.10323
Publication status	Published - 2003 Jan 1

Keywords

Human serum albumin
Hypoxia
Oxygen-carrying medicine
Solid tumor
Synthetic heme

ASJC Scopus subject areas

Ceramics and Composites
Biomaterials
Biomedical Engineering
Metals and Alloys

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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10.1002/jbm.a.10323

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Oxygenation of hypoxic region in solid tumor by administration of human serum albumin incorporating synthetic hemes. / Kobayashi, Koichi; Komatsu, Teruyuki; Iwamaru, Arifumi; Matsukawa, Yasuko; Horinouchi, Hirohisa; Watanabe, Masazumi; Tsuchida, Eishun.

In: Journal of Biomedical Materials Research - Part A, Vol. 64, No. 1, 01.01.2003, p. 48-51.

Research output: Contribution to journal › Article › peer-review

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abstract = "Recombinant human serum albumin incorporating synthetic heme (rHSA-FeP) was tested for its ability to increase O2 tension in the hypoxia of the solid tumor rat model. By the direct administration of the rHSA-FeP solution (10 mL/kg) via the aorta descendens to the ascites hepatoma LY80 tumor on the right femur, the O2 tension of the hypoxic region immediately increased to 3.45 ± 1.43 Torr, which corresponds to a 2.4-fold increase compared to that of the baseline value. These high O2 levels continued for 300 s after the infusion. The rHSA-FeP solution can be utilized not only as a red blood cell substitute but also as an O2-carrying medicine for the effective reoxygenation of the hypoxia solid tumor.",

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AU - Kobayashi, Koichi

AU - Komatsu, Teruyuki

AU - Iwamaru, Arifumi

AU - Matsukawa, Yasuko

AU - Horinouchi, Hirohisa

AU - Watanabe, Masazumi

AU - Tsuchida, Eishun

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AB - Recombinant human serum albumin incorporating synthetic heme (rHSA-FeP) was tested for its ability to increase O2 tension in the hypoxia of the solid tumor rat model. By the direct administration of the rHSA-FeP solution (10 mL/kg) via the aorta descendens to the ascites hepatoma LY80 tumor on the right femur, the O2 tension of the hypoxic region immediately increased to 3.45 ± 1.43 Torr, which corresponds to a 2.4-fold increase compared to that of the baseline value. These high O2 levels continued for 300 s after the infusion. The rHSA-FeP solution can be utilized not only as a red blood cell substitute but also as an O2-carrying medicine for the effective reoxygenation of the hypoxia solid tumor.

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KW - Oxygen-carrying medicine

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KW - Synthetic heme

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Oxygenation of hypoxic region in solid tumor by administration of human serum albumin incorporating synthetic hemes

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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