Oxygenation of hypoxic region in solid tumor by administration of human serum albumin incorporating synthetic hemes

Koichi Kobayashi, Teruyuki Komatsu, Arifumi Iwamaru, Yasuko Matsukawa, Hirohisa Horinouchi, Masazumi Watanabe, Eishun Tsuchida

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Recombinant human serum albumin incorporating synthetic heme (rHSA-FeP) was tested for its ability to increase O2 tension in the hypoxia of the solid tumor rat model. By the direct administration of the rHSA-FeP solution (10 mL/kg) via the aorta descendens to the ascites hepatoma LY80 tumor on the right femur, the O2 tension of the hypoxic region immediately increased to 3.45 ± 1.43 Torr, which corresponds to a 2.4-fold increase compared to that of the baseline value. These high O2 levels continued for 300 s after the infusion. The rHSA-FeP solution can be utilized not only as a red blood cell substitute but also as an O2-carrying medicine for the effective reoxygenation of the hypoxia solid tumor.

Original languageEnglish
Pages (from-to)48-51
Number of pages4
JournalJournal of Biomedical Materials Research - Part A
Volume64
Issue number1
DOIs
Publication statusPublished - 2003 Jan 1

Keywords

  • Human serum albumin
  • Hypoxia
  • Oxygen-carrying medicine
  • Solid tumor
  • Synthetic heme

ASJC Scopus subject areas

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

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