Abstract
Recombinant human serum albumin incorporating synthetic heme (rHSA-FeP) was tested for its ability to increase O2 tension in the hypoxia of the solid tumor rat model. By the direct administration of the rHSA-FeP solution (10 mL/kg) via the aorta descendens to the ascites hepatoma LY80 tumor on the right femur, the O2 tension of the hypoxic region immediately increased to 3.45 ± 1.43 Torr, which corresponds to a 2.4-fold increase compared to that of the baseline value. These high O2 levels continued for 300 s after the infusion. The rHSA-FeP solution can be utilized not only as a red blood cell substitute but also as an O2-carrying medicine for the effective reoxygenation of the hypoxia solid tumor.
Original language | English |
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Pages (from-to) | 48-51 |
Number of pages | 4 |
Journal | Journal of Biomedical Materials Research - Part A |
Volume | 64 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2003 Jan 1 |
Keywords
- Human serum albumin
- Hypoxia
- Oxygen-carrying medicine
- Solid tumor
- Synthetic heme
ASJC Scopus subject areas
- Ceramics and Composites
- Biomaterials
- Biomedical Engineering
- Metals and Alloys