Oxygenation of hypoxic region in solid tumor by administration of human serum albumin incorporating synthetic hemes

Koichi Kobayashi, Teruyuki Komatsu, Arifumi Iwamaru, Yasuko Matsukawa, Hirohisa Horinouchi, Masazumi Watanabe, Eishun Tsuchida

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12 Citations (Scopus)


Recombinant human serum albumin incorporating synthetic heme (rHSA-FeP) was tested for its ability to increase O2 tension in the hypoxia of the solid tumor rat model. By the direct administration of the rHSA-FeP solution (10 mL/kg) via the aorta descendens to the ascites hepatoma LY80 tumor on the right femur, the O2 tension of the hypoxic region immediately increased to 3.45 ± 1.43 Torr, which corresponds to a 2.4-fold increase compared to that of the baseline value. These high O2 levels continued for 300 s after the infusion. The rHSA-FeP solution can be utilized not only as a red blood cell substitute but also as an O2-carrying medicine for the effective reoxygenation of the hypoxia solid tumor.

Original languageEnglish
Pages (from-to)48-51
Number of pages4
JournalJournal of Biomedical Materials Research - Part A
Issue number1
Publication statusPublished - 2003 Jan 1



  • Human serum albumin
  • Hypoxia
  • Oxygen-carrying medicine
  • Solid tumor
  • Synthetic heme

ASJC Scopus subject areas

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

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