Abstract
Recombinant human serum albumin incorporating synthetic heme (rHSA-FeP) was tested for its ability to increase O2 tension in the hypoxia of the solid tumor rat model. By the direct administration of the rHSA-FeP solution (10 mL/kg) via the aorta descendens to the ascites hepatoma LY80 tumor on the right femur, the O2 tension of the hypoxic region immediately increased to 3.45 ± 1.43 Torr, which corresponds to a 2.4-fold increase compared to that of the baseline value. These high O2 levels continued for 300 s after the infusion. The rHSA-FeP solution can be utilized not only as a red blood cell substitute but also as an O2-carrying medicine for the effective reoxygenation of the hypoxia solid tumor.
| Original language | English |
|---|---|
| Pages (from-to) | 48-51 |
| Number of pages | 4 |
| Journal | Journal of Biomedical Materials Research - Part A |
| Volume | 64 |
| Issue number | 1 |
| Publication status | Published - 2003 Jan 1 |
Fingerprint
Keywords
- Human serum albumin
- Hypoxia
- Oxygen-carrying medicine
- Solid tumor
- Synthetic heme
ASJC Scopus subject areas
- Biomedical Engineering
- Biomaterials
Cite this
Oxygenation of hypoxic region in solid tumor by administration of human serum albumin incorporating synthetic hemes. / Kobayashi, Koichi; Komatsu, Teruyuki; Iwamaru, Arifumi; Matsukawa, Yasuko; Horinouchi, Hirohisa; Watanabe, Masazumi; Tsuchida, Eishun.
In: Journal of Biomedical Materials Research - Part A, Vol. 64, No. 1, 01.01.2003, p. 48-51.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Oxygenation of hypoxic region in solid tumor by administration of human serum albumin incorporating synthetic hemes
AU - Kobayashi, Koichi
AU - Komatsu, Teruyuki
AU - Iwamaru, Arifumi
AU - Matsukawa, Yasuko
AU - Horinouchi, Hirohisa
AU - Watanabe, Masazumi
AU - Tsuchida, Eishun
PY - 2003/1/1
Y1 - 2003/1/1
N2 - Recombinant human serum albumin incorporating synthetic heme (rHSA-FeP) was tested for its ability to increase O2 tension in the hypoxia of the solid tumor rat model. By the direct administration of the rHSA-FeP solution (10 mL/kg) via the aorta descendens to the ascites hepatoma LY80 tumor on the right femur, the O2 tension of the hypoxic region immediately increased to 3.45 ± 1.43 Torr, which corresponds to a 2.4-fold increase compared to that of the baseline value. These high O2 levels continued for 300 s after the infusion. The rHSA-FeP solution can be utilized not only as a red blood cell substitute but also as an O2-carrying medicine for the effective reoxygenation of the hypoxia solid tumor.
AB - Recombinant human serum albumin incorporating synthetic heme (rHSA-FeP) was tested for its ability to increase O2 tension in the hypoxia of the solid tumor rat model. By the direct administration of the rHSA-FeP solution (10 mL/kg) via the aorta descendens to the ascites hepatoma LY80 tumor on the right femur, the O2 tension of the hypoxic region immediately increased to 3.45 ± 1.43 Torr, which corresponds to a 2.4-fold increase compared to that of the baseline value. These high O2 levels continued for 300 s after the infusion. The rHSA-FeP solution can be utilized not only as a red blood cell substitute but also as an O2-carrying medicine for the effective reoxygenation of the hypoxia solid tumor.
KW - Human serum albumin
KW - Hypoxia
KW - Oxygen-carrying medicine
KW - Solid tumor
KW - Synthetic heme
UR - http://www.scopus.com/inward/record.url?scp=0346851946&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0346851946&partnerID=8YFLogxK
M3 - Article
C2 - 12483695
AN - SCOPUS:0346851946
VL - 64
SP - 48
EP - 51
JO - Journal of Biomedical Materials Research
JF - Journal of Biomedical Materials Research
SN - 1549-3296
IS - 1
ER -