P2y purinergic receptors coupled to phosphoinositide hydrolysis in tissues of the cochlear lateral wall

Kaoru Ogawa, Jochen Schacht

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

THE tissues of the lateral wall of the cochlea, spiral ligament and stria vascularis, maintain homeostasis of the inner ear through the production of endolymph and regulation of cochlear blood flow. We examined the effects of purinergic agonists on the release of inositol phosphates (InsPs) in intact isolated lateral wall tissues of the Fischer-344 rat. After preincubation with myo- [3H]inositol, stimulation with the P2 purinergic agonist ATP-γ-S resulted in a concentration-dependent increase in the formation of [3H]InsPs. The P2 purinergic agonist α,β-methylene ATP (AMP-CPP) was a weaker stimulant, and the PI purinergic agonist adenosine was ineffective. These results are consistent with the presence of P2y receptors and a purinergically controlled InsP3 second messenger system in the cochlear lateral wall.

Original languageEnglish
Pages (from-to)1538-1540
Number of pages3
JournalNeuroReport
Volume6
Issue number11
DOIs
Publication statusPublished - 1995 Jul

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Keywords

  • Cochlea
  • Inositol phosphates
  • Lateral wall
  • Punnore-ceptors
  • Rat
  • Second messenger
  • Spiral ligament
  • Stria vascularis

ASJC Scopus subject areas

  • Neuroscience(all)

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