p53 Gene Mutation in Recurrent Superficial Bladder Cancer

Ichiro Yoshimura, Jun Kudo, Shiro Saito, Hiroshi Tazaki, Nobuyoshi Shimizu

Research output: Contribution to journalArticle

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Abstract

Surgical specimens from 30 patients with transitional cell carcinoma of the bladder were examined for the presence of mutation of the p53 tumor suppressor gene using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis. All of the specimens were superficial, low grade cancer, and 10 patients had recurrences during an observation period of 24 months following the initial surgical treatment. Among the 30 patients with superficial bladder cancer, 4 were found to have the mutated p53 gene and 3 of them had recurrences, which involved either invasive or high grade tumors. Two of these recurrent tumors with the p53 gene mutation showed identical mutations with those primary tumors, whereas the other one did not have the same mutation. The data suggest that bladder cancers with a mutation of the p53 gene have a greater probability of poor prognosis than those which do not, even if the primary lesion was a superficial, low grade tumor. Therefore, the presence of the p53 gene mutation may provide important clues to the factors involved in bladder cancer.

Original languageEnglish
Pages (from-to)1711-1715
Number of pages5
JournalThe Journal of Urology
Volume153
Issue number5
DOIs
Publication statusPublished - 1995

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p53 Genes
Urinary Bladder Neoplasms
Mutation
Neoplasms
Recurrence
Transitional Cell Carcinoma
Tumor Suppressor Genes
Urinary Bladder
Observation
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Urology

Cite this

Yoshimura, I., Kudo, J., Saito, S., Tazaki, H., & Shimizu, N. (1995). p53 Gene Mutation in Recurrent Superficial Bladder Cancer. The Journal of Urology, 153(5), 1711-1715. https://doi.org/10.1016/S0022-5347(01)67510-4

p53 Gene Mutation in Recurrent Superficial Bladder Cancer. / Yoshimura, Ichiro; Kudo, Jun; Saito, Shiro; Tazaki, Hiroshi; Shimizu, Nobuyoshi.

In: The Journal of Urology, Vol. 153, No. 5, 1995, p. 1711-1715.

Research output: Contribution to journalArticle

Yoshimura, I, Kudo, J, Saito, S, Tazaki, H & Shimizu, N 1995, 'p53 Gene Mutation in Recurrent Superficial Bladder Cancer', The Journal of Urology, vol. 153, no. 5, pp. 1711-1715. https://doi.org/10.1016/S0022-5347(01)67510-4
Yoshimura, Ichiro ; Kudo, Jun ; Saito, Shiro ; Tazaki, Hiroshi ; Shimizu, Nobuyoshi. / p53 Gene Mutation in Recurrent Superficial Bladder Cancer. In: The Journal of Urology. 1995 ; Vol. 153, No. 5. pp. 1711-1715.
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