p53 gene mutations in early colorectal carcinoma. De novo vs. adenoma-carcinoma sequence

H. Hasegawa, M. Ueda, K. Furukawa, M. Watanabe, T. Teramoto, M. Mukai, M. Kitajima

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

p53 gene mutations;n early and advanced colorectal cancer were detected by PCR-SSCP analysis. Early colorectal cancer was classified into de novo cancer and polyp-forming cancer, respectively, according to morphology and presence of adenomatous components. A total of 94 paraffin-embedded tissue specimens from patients with colorectal cancer were analysed. p53 gene mutations were detected in 40.0% (12/30) of de novo cancer, 36.7% (11/30) of polyp-forming cancer, and 44% (15/34) of advanced cancer. p53 mutations were detected at a high frequency in both types of early colorectal cancer as well as in advanced cancer. No correlations were found between p53 mutations and clinicopathological data. Our data suggest that the p53 gene mutations occurred in the early colorectal cancer stage of carcinogenes regardless of the pathway.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalInternational Journal of Cancer
Volume64
Issue number1
DOIs
Publication statusPublished - 1995

Fingerprint

p53 Genes
Adenoma
Colorectal Neoplasms
Carcinoma
Mutation
Neoplasms
Polyps
Single-Stranded Conformational Polymorphism
Paraffin
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Hasegawa, H., Ueda, M., Furukawa, K., Watanabe, M., Teramoto, T., Mukai, M., & Kitajima, M. (1995). p53 gene mutations in early colorectal carcinoma. De novo vs. adenoma-carcinoma sequence. International Journal of Cancer, 64(1), 47-51. https://doi.org/10.1002/ijc.2910640110

p53 gene mutations in early colorectal carcinoma. De novo vs. adenoma-carcinoma sequence. / Hasegawa, H.; Ueda, M.; Furukawa, K.; Watanabe, M.; Teramoto, T.; Mukai, M.; Kitajima, M.

In: International Journal of Cancer, Vol. 64, No. 1, 1995, p. 47-51.

Research output: Contribution to journalArticle

Hasegawa, H, Ueda, M, Furukawa, K, Watanabe, M, Teramoto, T, Mukai, M & Kitajima, M 1995, 'p53 gene mutations in early colorectal carcinoma. De novo vs. adenoma-carcinoma sequence', International Journal of Cancer, vol. 64, no. 1, pp. 47-51. https://doi.org/10.1002/ijc.2910640110
Hasegawa, H. ; Ueda, M. ; Furukawa, K. ; Watanabe, M. ; Teramoto, T. ; Mukai, M. ; Kitajima, M. / p53 gene mutations in early colorectal carcinoma. De novo vs. adenoma-carcinoma sequence. In: International Journal of Cancer. 1995 ; Vol. 64, No. 1. pp. 47-51.
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