P53 protein accumulation, iodine-unstained lesions, and alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 genotypes in Japanese alcoholic men with esophageal dysplasia

Akira Yokoyama, Yoichi Tanaka, Tetsuji Yokoyama, Takeshi Mizukami, Toshifumi Matsui, Katsuya Maruyama, Tai Omori

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Inactive heterozygous aldehyde dehydrogenase-2 (ALDH2*1/*2) and less-active alcohol dehydrogenase-1B (ADH1B*1/*1) increase the risk of esophageal cancer in East Asian drinkers, and esophageal cancer multiplicity is strongly associated with ALDH2*1/*2. p53 alterations are key molecular events in multifocal carcinogenesis in the esophagus. We studied 260 esophageal-cancer free Japanese alcoholics with esophageal dysplasia diagnosed by biopsy of distinct iodine-unstained lesions (DIULs) ≥5. mm. The degree of p53 protein accumulation was positively associated with the degree of atypia (p<0.0001) and size (p=0.040) of DIULs and with the presence of multiple DIULs (p. =0.070), but not with ALDH2*1/*2 or ADH1B*1/*1.

Original languageEnglish
Pages (from-to)112-117
Number of pages6
JournalCancer Letters
Issue number1
Publication statusPublished - 2011 Sep 1



  • Alcohol
  • Alcohol dehydrogenase-1B
  • Aldehyde dehydrogenase-2
  • Esophageal dysplasia
  • P53

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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