p59fyn-p125FAK cooperation in Development of CD4+CD8+ Thymocytes

Satoshi Kanazawa, Duško Ilić, Motohiro Hashiyama, Tetsuo Noumura, Tadashi Yamamoto, Toshio Suda, Shinichi Aizawa

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

p59fyn is an Src family nonreceptor tyrosine kinase that has been suggested to play an important role in T-cell development and function. p125FAK is a unique nonreceptor tyrosine kinase and has been known to respond to integrin-extracellular matrix interactions. To examine their roles in thymocytes, heterozygous fak mutation was introduced into homozygous Fyn deficiency. The double mutation, but neither Fyn deficiency nor FAK heterozygosity alone, displayed impaired development of CD4+CD8+ thymocytes with atrophy of the thymic cortex, suggesting a unique cooperation between P59fyn and p125FAK in CD4+CD8+ T-cell development.

Original languageEnglish
Pages (from-to)865-870
Number of pages6
JournalBlood
Volume87
Issue number3
DOIs
Publication statusPublished - 1996 Feb 1

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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