Approximately 4% of the Japanese population genetically lack plasma platelet activating factor acetylhydrolase (PAF-AH) and show a higher prevalence of thromboembolic disease, but whether they are susceptible to another PAF-related disease, asthma, remains controversial. To determine the role of plasma PAF-AH in airway physiology, we performed PAF bronchoprovocation tests in 8 plasma PAF-AH-deficient subjects and 16 control subjects. Serial inhalation of PAF (1-1000μg/ml) concentration-dependently induced acute bronchoconstriction, but there was no significant difference between PAF-AH-deficient and control subjects (11.7±4.6% vs. 9.6±2.8% decrease in forced expiratory volume in 1s). Transient neutropenia after single inhalation of PAF (1000μg/ml) showed no significant difference between the groups either in its magnitude (72±11% vs. 65±9% decrease) or duration (4.1±1.0 vs. 3.3±0.8min). In conclusion, a lack of plasma PAF-AH activity alone does not augment physiological responses to PAF in the airway.
|Number of pages||6|
|Journal||Biochemical and Biophysical Research Communications|
|Publication status||Published - 2004 Apr 23|
- Airway responsiveness
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology