PAF responsiveness in Japanese subjects with plasma PAF acetylhydrolase deficiency

Katsuhiko Naoki, Koichiro Asano, Nagato Satoh, Kouichi Fukunaga, Tsuyoshi Oguma, Tetsuya Shiomi, Yusuke Suzuki, Takeshi Nakajima, Kyoko Niimi, Yoshiki Shiraishi, Akitoshi Ishizaka, Kazuhiro Yamaguchi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Approximately 4% of the Japanese population genetically lack plasma platelet activating factor acetylhydrolase (PAF-AH) and show a higher prevalence of thromboembolic disease, but whether they are susceptible to another PAF-related disease, asthma, remains controversial. To determine the role of plasma PAF-AH in airway physiology, we performed PAF bronchoprovocation tests in 8 plasma PAF-AH-deficient subjects and 16 control subjects. Serial inhalation of PAF (1-1000μg/ml) concentration-dependently induced acute bronchoconstriction, but there was no significant difference between PAF-AH-deficient and control subjects (11.7±4.6% vs. 9.6±2.8% decrease in forced expiratory volume in 1s). Transient neutropenia after single inhalation of PAF (1000μg/ml) showed no significant difference between the groups either in its magnitude (72±11% vs. 65±9% decrease) or duration (4.1±1.0 vs. 3.3±0.8min). In conclusion, a lack of plasma PAF-AH activity alone does not augment physiological responses to PAF in the airway.

Original languageEnglish
Pages (from-to)205-210
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume317
Issue number1
DOIs
Publication statusPublished - 2004 Apr 23

    Fingerprint

Keywords

  • Airway responsiveness
  • Asthma
  • Neutrophil

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Naoki, K., Asano, K., Satoh, N., Fukunaga, K., Oguma, T., Shiomi, T., Suzuki, Y., Nakajima, T., Niimi, K., Shiraishi, Y., Ishizaka, A., & Yamaguchi, K. (2004). PAF responsiveness in Japanese subjects with plasma PAF acetylhydrolase deficiency. Biochemical and Biophysical Research Communications, 317(1), 205-210. https://doi.org/10.1016/j.bbrc.2004.03.031