Palladium-Catalyzed C-H Iodination of N-(8-Quinolinyl)benzamide Derivatives Under Electrochemical and Non-Electrochemical Conditions

Katsuya Sano, Naoki Kimura, Takuya Kochi, Fumitoshi Kakiuchi

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2 Citations (Scopus)

Abstract

Palladium-catalyzed ortho-selective C-H iodination of N-(8-quinolinyl)benzamides proceeded using I2 under both electrochemical and non-electrochemical conditions. The C-H iodination at 90°C under base-free conditions provided high yields of the iodination products. The use of anodic oxidation increased the efficiency of the iodination at sterically-hindered positions.

Original languageEnglish
JournalAsian Journal of Organic Chemistry
DOIs
Publication statusAccepted/In press - 2018 Jan 1

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Keywords

  • Benzamides
  • C-H activation
  • Electrochemical oxidation
  • Iodine
  • Palladium

ASJC Scopus subject areas

  • Organic Chemistry

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