Palladium-Catalyzed C−H Iodination of N-(8-Quinolinyl)benzamide Derivatives Under Electrochemical and Non-Electrochemical Conditions

Katsuya Sano, Naoki Kimura, Takuya Kochi, Fumitoshi Kakiuchi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Palladium-catalyzed ortho-selective C−H iodination of N-(8-quinolinyl)benzamides proceeded using I2 under both electrochemical and non-electrochemical conditions. The C−H iodination at 90 °C under base-free conditions provided high yields of the iodination products. The use of anodic oxidation increased the efficiency of the iodination at sterically-hindered positions.

Original languageEnglish
Pages (from-to)1311-1314
Number of pages4
JournalAsian Journal of Organic Chemistry
Volume7
Issue number7
DOIs
Publication statusPublished - 2018 Jul

Keywords

  • C−H activation
  • benzamides
  • electrochemical oxidation
  • iodine
  • palladium

ASJC Scopus subject areas

  • Organic Chemistry

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