Palladium-Catalyzed Hydroboration/Cyclization of 1, n-Dienes

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While the hydroboration of alkenes is well established, the corresponding cyclization reaction of dienes remains challenging. Here, we report a new method for hydroboration/cyclization applicable to various 1,n-dienes and hydroboranes. The method features the direct synthesis of borylalkyl cyclopentanes from common 1,6-dienes, which is highlighted by syntheses of elaborated pyrrolidine cores from easily accessible diallylamines. Notably, 1,n-dienes (n > 6) also undergo five-membered ring formation, offering "remote"hydroboration/cyclization that would be otherwise difficult to achieve.

Original languageEnglish
JournalJournal of Organic Chemistry
Publication statusAccepted/In press - 2022

ASJC Scopus subject areas

  • Organic Chemistry


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