Palladium-Catalyzed Remote Diborylative Cyclization of Dienes with Diborons via Chain Walking

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6 Citations (Scopus)

Abstract

A novel method for catalytic remote bismetalation of alkene substrates by the addition of dimetal reagents is accomplished by using chain walking. In the presence of a palladium catalyst, the reaction of various 1,n-dienes and diborons were converted into cyclopentane derivatives with two boryl groups at remote positions via facile regioselective transformation of an unactivated sp3 C-H bond to a C-B bond. Sequential construction of three distant bonds, which is difficult to achieve by any method, was accomplished for the reactions of 1,n-dienes (n ≥ 7).

Original languageEnglish
Pages (from-to)19275-19281
Number of pages7
JournalJournal of the American Chemical Society
Volume143
Issue number46
DOIs
Publication statusPublished - 2021 Nov 24

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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