TY - JOUR
T1 - Pancreas duct abnormalities in patients with ulcerative colitis
T2 - A magnetic resonance pancreatography study
AU - Toda, Nobuo
AU - Akahane, Masaaki
AU - Kiryu, Shigeru
AU - Matsubara, Yasuo
AU - Yamaji, Yutaka
AU - Okamoto, Makoto
AU - Minagawa, Nobuyuki
AU - Ohgi, Kazuyuki
AU - Komatsu, Yutaka
AU - Yahagi, Naohisa
AU - Yoshida, Haruhiko
AU - Kawabe, Takao
AU - Ohtomo, Kuni
AU - Omata, Masao
PY - 2005/10
Y1 - 2005/10
N2 - Background: The presumed etiology and prevalence of pancreatic abnormalities in patients with ulcerative colitis (UC) have been controversial. We conducted a controlled (cross-sectional) study of patients with UC compared with non-UC controls to determine the prevalence of pancreatic duct abnormalities in patients with UC and to determine if these are specific to UC using magnetic resonance cholangiopancreatography. Methods: Magnetic resonance cholangiopancreatography was performed on 79 unselected patients with UC and 45 non-UC controls, without a history of pancreatitis attack, between February 2000 and May 2003. Results: Among patients with UC, the prevalence of pancreatic duct abnormalities was 16.4% (95% confidence interval, 8.3%-24.6%): coexisting dilatation and narrowing of the main pancreatic duct were found in 5; diffuse narrowing of pancreatic ducts in 5; and dilatation of pancreatic ductal branches in 3. These abnormalities were compatible with chronic pancreatitis. Among the controls, no pancreatic duct abnormality was found. Conclusions: Changes in the pancreatic duct were found in approximately one-sixth of patients with UC, none of whom had a history of overt pancreatitis. These pancreatic duct abnormalities are likely to be specific to patients with UC.
AB - Background: The presumed etiology and prevalence of pancreatic abnormalities in patients with ulcerative colitis (UC) have been controversial. We conducted a controlled (cross-sectional) study of patients with UC compared with non-UC controls to determine the prevalence of pancreatic duct abnormalities in patients with UC and to determine if these are specific to UC using magnetic resonance cholangiopancreatography. Methods: Magnetic resonance cholangiopancreatography was performed on 79 unselected patients with UC and 45 non-UC controls, without a history of pancreatitis attack, between February 2000 and May 2003. Results: Among patients with UC, the prevalence of pancreatic duct abnormalities was 16.4% (95% confidence interval, 8.3%-24.6%): coexisting dilatation and narrowing of the main pancreatic duct were found in 5; diffuse narrowing of pancreatic ducts in 5; and dilatation of pancreatic ductal branches in 3. These abnormalities were compatible with chronic pancreatitis. Among the controls, no pancreatic duct abnormality was found. Conclusions: Changes in the pancreatic duct were found in approximately one-sixth of patients with UC, none of whom had a history of overt pancreatitis. These pancreatic duct abnormalities are likely to be specific to patients with UC.
KW - Magnetic resonance cholangiopancreatography
KW - Pancreatitis
KW - Ulcerative colitis
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U2 - 10.1097/01.MIB.0000183419.17563.17
DO - 10.1097/01.MIB.0000183419.17563.17
M3 - Article
C2 - 16189420
AN - SCOPUS:26444448456
VL - 11
SP - 903
EP - 908
JO - Inflammatory Bowel Diseases
JF - Inflammatory Bowel Diseases
SN - 1078-0998
IS - 10
ER -