Pancreas duct abnormalities in patients with ulcerative colitis: A magnetic resonance pancreatography study

Nobuo Toda, Masaaki Akahane, Shigeru Kiryu, Yasuo Matsubara, Yutaka Yamaji, Makoto Okamoto, Nobuyuki Minagawa, Kazuyuki Ohgi, Yutaka Komatsu, Naohisa Yahagi, Haruhiko Yoshida, Takao Kawabe, Kuni Ohtomo, Masao Omata

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: The presumed etiology and prevalence of pancreatic abnormalities in patients with ulcerative colitis (UC) have been controversial. We conducted a controlled (cross-sectional) study of patients with UC compared with non-UC controls to determine the prevalence of pancreatic duct abnormalities in patients with UC and to determine if these are specific to UC using magnetic resonance cholangiopancreatography. Methods: Magnetic resonance cholangiopancreatography was performed on 79 unselected patients with UC and 45 non-UC controls, without a history of pancreatitis attack, between February 2000 and May 2003. Results: Among patients with UC, the prevalence of pancreatic duct abnormalities was 16.4% (95% confidence interval, 8.3%-24.6%): coexisting dilatation and narrowing of the main pancreatic duct were found in 5; diffuse narrowing of pancreatic ducts in 5; and dilatation of pancreatic ductal branches in 3. These abnormalities were compatible with chronic pancreatitis. Among the controls, no pancreatic duct abnormality was found. Conclusions: Changes in the pancreatic duct were found in approximately one-sixth of patients with UC, none of whom had a history of overt pancreatitis. These pancreatic duct abnormalities are likely to be specific to patients with UC.

Original languageEnglish
Pages (from-to)903-908
Number of pages6
JournalInflammatory bowel diseases
Volume11
Issue number10
DOIs
Publication statusPublished - 2005 Oct 1
Externally publishedYes

Keywords

  • Magnetic resonance cholangiopancreatography
  • Pancreatitis
  • Ulcerative colitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Gastroenterology

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    Toda, N., Akahane, M., Kiryu, S., Matsubara, Y., Yamaji, Y., Okamoto, M., Minagawa, N., Ohgi, K., Komatsu, Y., Yahagi, N., Yoshida, H., Kawabe, T., Ohtomo, K., & Omata, M. (2005). Pancreas duct abnormalities in patients with ulcerative colitis: A magnetic resonance pancreatography study. Inflammatory bowel diseases, 11(10), 903-908. https://doi.org/10.1097/01.MIB.0000183419.17563.17