Papillary carcinoma occurring within an adenomatous goiter of the thyroid gland in Cowden's disease

Kaori Kameyama, H. Takami, K. Miyajima, T. Mimura, Y. Hosoda, K. Ito, K. Ito

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Cowden's disease is an autosomal dominant disorder characterized by multiple benign and malignant neoplastic lesions involving many organs. The presence of characteristic cutaneous lesions is crucial for the diagnosis. Thyroid disease is a major extracutaneous manifestation of this disease; however, the histologic characteristics have not been described in detail. We report a case of thyroid tumor associated with Cowden's disease. Grossly, the tumor showed a multinodular appearance, like an adenomatous goiter. Microscopically, it consisted of follicular adenomas with a trabecular pattern. Some of the nodules had a second component resembling papillary carcinoma. This was thought to be a unique histological feature not described previously, and might be specific to thyroid tumor associated with Cowden's disease.

Original languageEnglish
Pages (from-to)73-76
Number of pages4
JournalEndocrine Pathology
Volume12
Issue number1
DOIs
Publication statusPublished - 2001

Fingerprint

Multiple Hamartoma Syndrome
Papillary Carcinoma
Goiter
Thyroid Gland
Neoplasms
Thyroid Diseases
Adenoma
Skin

Keywords

  • Adenomatous goiter
  • Cowden's disease
  • Papillary carcinoma
  • PTEN gene
  • Thyroid

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Papillary carcinoma occurring within an adenomatous goiter of the thyroid gland in Cowden's disease. / Kameyama, Kaori; Takami, H.; Miyajima, K.; Mimura, T.; Hosoda, Y.; Ito, K.; Ito, K.

In: Endocrine Pathology, Vol. 12, No. 1, 2001, p. 73-76.

Research output: Contribution to journalArticle

Kameyama, Kaori ; Takami, H. ; Miyajima, K. ; Mimura, T. ; Hosoda, Y. ; Ito, K. ; Ito, K. / Papillary carcinoma occurring within an adenomatous goiter of the thyroid gland in Cowden's disease. In: Endocrine Pathology. 2001 ; Vol. 12, No. 1. pp. 73-76.
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